Bond M G, Wilmoth S K, Enevold G L, Strickland H L
Department of Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27103.
Am J Med. 1989 Apr 17;86(4A):33-6. doi: 10.1016/0002-9343(89)90187-3.
Methods are currently available to noninvasively detect and evaluate asymptomatic atherosclerosis in the carotid artery, and provide a unique opportunity to monitor the effect of medical intervention during the early stages of atherosclerotic progression. When using high-resolution B-mode ultrasound to monitor lesion change over time, it is the reproducibility of measurements at the arterial wall and lumen that defines the confidence of establishing rates of disease progression. Previous studies have demonstrated that, in a research environment using standardized protocols for scanning and interpretation, the absolute difference between blinded replicate measurements of arterial wall thicknesses at sites of lesion is less than 0.2 mm. The Multicenter Isradipine Diuretic Atherosclerosis Study will use high-resolution B-mode ultrasound to determine the effect of isradipine and hydrochlorothiazide on the rate of progression of carotid artery atherosclerosis in hypertensive subjects. Methods for scanning and interpretation of arterial wall thickenings are presented.
目前已有方法可用于非侵入性检测和评估颈动脉无症状性动脉粥样硬化，并为监测动脉粥样硬化进展早期阶段的医学干预效果提供了独特的机会。当使用高分辨率B型超声监测病变随时间的变化时，动脉壁和管腔测量的可重复性决定了确定疾病进展速率的可信度。先前的研究表明，在采用标准化扫描和解读方案的研究环境中，病变部位动脉壁厚度的双盲重复测量之间的绝对差异小于0.2毫米。多中心伊拉地平利尿剂动脉粥样硬化研究将使用高分辨率B型超声来确定伊拉地平和氢氯噻嗪对高血压患者颈动脉粥样硬化进展速率的影响。本文介绍了动脉壁增厚的扫描和解读方法。
