Furberg C D, Byington R P, Borhani N A
Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103.
Am J Med. 1989 Apr 17;86(4A):37-9. doi: 10.1016/0002-9343(89)90188-5.
The Multicenter Isradipine Diuretic Atherosclerosis Study is a randomized, double-blind, clinical trial designed to compare the effectiveness of isradipine against hydrochlorothiazide in retarding the rate of progression of atherosclerotic lesions in the carotid arteries of hypertensive subjects. Eight hundred hypertensive men and women, 40 years of age or older, with minor plaques, are being recruited at eight clinical centers in the United States and will be followed for three years. Quantification of the atherosclerotic lesions at baseline and semiannually is done using B-mode ultrasonography. The background of the trial and its design features are discussed.
多中心异搏定-利尿剂动脉粥样硬化研究是一项随机、双盲临床试验，旨在比较异搏定与氢氯噻嗪在延缓高血压患者颈动脉粥样硬化病变进展速度方面的有效性。在美国的八个临床中心招募了800名年龄在40岁及以上、有轻度斑块的高血压男性和女性，他们将被随访三年。使用B型超声对基线和每半年的动脉粥样硬化病变进行量化。文中讨论了该试验的背景及其设计特点。
