Narsaria P, Singh S, Gupta A, Khullar M, Bhalla A
Paediatric Allergy Immunology and Physical Anthropology Units, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Clin Exp Rheumatol. 2015 Mar-Apr;33(2 Suppl 89):S-171-5. Epub 2014 Sep 19.
Kawasaki disease (KD) is an acute vasculitis that can result in coronary artery abnormalities (CAA). Higher risk of atherosclerosis has also been documented in those who do not develop CAA. We report herein the lipid profile and fat patterning in children with KD in a cohort from Northern India at a mean follow-up of 8.8 years after the acute stage. There is a paucity of literature on this aspect of KD.
Twenty children, who had developed KD at least 5 years previously were enrolled along with age- and sex-matched controls. Cases and controls underwent anthropometric assessment using standardised techniques and instruments. Lipids were assayed only in the cases.
There was no significant difference in weight, height, mid-upper arm circumference, waist circumference, hip circumference and waist-to-hip ratio between cases and controls. Skinfold thickness (ST) at triceps, subscapular, midaxillary and suprailiac regions was similar in cases and controls. Biceps and medial calf ST was, however, significantly higher among girls with KD in 10-14.9 years age group. On comparison with cut-offs enumerated by the National Cholesterol Education Program (NCEP), 2 children with KD had borderline while 1 had undesirable levels of total cholesterol. Undesirable triglyceride levels were seen in 12 children. Ten children had HDL levels <35 mg/dl while 1 had borderline LDL levels.
Lipid abnormalities at a mean of 8.8 years after KD suggest that these patients may be prone to premature atherosclerosis. There were no significant differences in the anthropometric parameters and most of the ST.
川崎病（KD）是一种急性血管炎，可导致冠状动脉异常（CAA）。在未发生CAA的患者中也有更高的动脉粥样硬化风险记录。我们在此报告印度北部一个队列中KD患儿在急性期后平均8.8年随访时的血脂谱和脂肪分布情况。关于KD这方面的文献较少。
纳入20名至少在5年前患过KD的儿童以及年龄和性别匹配的对照组。病例组和对照组使用标准化技术和仪器进行人体测量评估。仅对病例组进行血脂检测。
病例组和对照组在体重、身高、上臂中部周长、腰围、臀围和腰臀比方面无显著差异。肱三头肌、肩胛下、腋中及髂嵴上区域的皮褶厚度（ST）在病例组和对照组中相似。然而，在10 - 14.9岁年龄组的KD女童中，肱二头肌和小腿内侧ST显著更高。与美国国家胆固醇教育计划（NCEP）列举的临界值相比，2名KD患儿的总胆固醇处于临界水平，1名患儿的总胆固醇水平不理想。12名患儿的甘油三酯水平不理想。10名患儿的高密度脂蛋白（HDL）水平<35 mg/dl，1名患儿的低密度脂蛋白（LDL）水平处于临界状态。
KD后平均8.8年出现的血脂异常表明这些患者可能易患早发性动脉粥样硬化。人体测量参数和大多数皮褶厚度无显著差异。
