使用苯硫酚对烯烃进行需氧氧磺酰化反应：一种高效合成β-酮砜的一锅法路线。
Aerobic oxysulfonylation of alkenes using thiophenols: an efficient one-pot route to β-ketosulfones.
作者信息
Singh Atul K, Chawla Ruchi, Keshari Twinkle, Yadav Vinod K, Yadav Lal Dhar S
机构信息
Green Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad 211 002, India.
出版信息
Org Biomol Chem. 2014 Nov 14;12(42):8550-4. doi: 10.1039/c4ob00776j.
We have developed a highly efficient synthetic route to β-ketosulfones via AgNO3 catalyzed oxysulfonylation of alkenes using thiophenols in the presence of air (O2) and K2S2O8 as eco-friendly oxidants. Thiophenols have been used as sulfonylation precursors for the first time in a dioxygen activation based radical process. Moreover, the protocol also offers a new and convenient method for the synthesis of β-hydroxysulfides at room temperature without the use of any initiator.
我们已经开发出一种高效的合成路线，通过在空气（O₂）存在下，使用苯硫酚和K₂S₂O₈作为环境友好型氧化剂，经AgNO₃催化烯烃的氧磺酰化反应来制备β-酮砜。苯硫酚首次在基于双氧活化的自由基过程中用作磺酰化前体。此外，该方法还提供了一种在室温下无需使用任何引发剂即可合成β-羟基硫醚的新颖且便捷的方法。
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