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黑素细胞性皮肤病变的高清光学相干断层扫描

High-definition optical coherence tomography of melanocytic skin lesions.

作者信息

Gambichler Thilo, Plura Iris, Schmid-Wendtner Monika, Valavanis Konstantinos, Kulichova Daniela, Stücker Markus, Pljakic Azem, Berking Carola, Maier Tanja

机构信息

Department of Dermatology, Ruhr-University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany.

Interdisciplinary Oncology Center Munich, Munich, Germany.

出版信息

J Biophotonics. 2015 Aug;8(8):681-6. doi: 10.1002/jbio.201400085. Epub 2014 Sep 18.

Abstract

High-definition optical coherence tomography (HD-OCT) scanners have recently been developed. We assessed micromorphological HD-OCT correlates of benign naevi (BN) and malignant melanoma (MM). 28 BN and 20 MM were studied using HD-OCT and histology. Epidermal honeycomb/cobblestone pattern, regular junctional cell nests, and edged papillae are more often observed in BN, whereas fusion of rete ridges, pagetoid cells and junctional and/or dermal nests with atypical cells are more frequently seen in MM. A high overlap of HD-OCT features in BN and MM was observed and in 20% of MM we did not find evidence for malignancy in OCT images at all. Using HD-OCT it is possible to visualize architectural and cellular alterations of melanocytic skin lesions. The overlap of HD-OCT features seen in BN and MM and the absence of suspicious HD-OCT features in some MM represents an important limitation of HD-OCT affecting the sensitivity of HD-OCT in diagnosing MM. High-definition optical coherence tomography and the corresponding vertically sectioned histology of a compound naevus.

摘要

高分辨率光学相干断层扫描(HD-OCT)扫描仪最近已被开发出来。我们评估了良性痣(BN)和恶性黑色素瘤(MM)的微观形态学HD-OCT相关性。使用HD-OCT和组织学对28例BN和20例MM进行了研究。在BN中更常观察到表皮蜂窝状/鹅卵石样图案、规则的交界细胞巢和边缘乳头,而在MM中更常看到 rete 嵴融合、派杰样细胞以及带有非典型细胞的交界和/或真皮巢。观察到BN和MM的HD-OCT特征有高度重叠,并且在20%的MM中,我们在OCT图像中根本没有发现恶性的证据。使用HD-OCT可以可视化黑素细胞性皮肤病变的结构和细胞改变。BN和MM中HD-OCT特征的重叠以及一些MM中缺乏可疑的HD-OCT特征是HD-OCT的一个重要局限性,影响了HD-OCT在诊断MM中的敏感性。高分辨率光学相干断层扫描和复合痣相应的垂直切片组织学。

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