Kang Ji Won, Park Soo Kyoung
Department of Anesthesiology and Pain Medicine, Incheon St. Mary's Hospital, Incheon, Korea.
Department of Anesthesiology and Pain Medicine, International St. Mary's Hospital, Incheon, Korea.
Korean J Anesthesiol. 2014 Aug;67(2):110-4. doi: 10.4097/kjae.2014.67.2.110. Epub 2014 Aug 26.
The efficacy of palonosetron in preventing postoperative nausea and vomiting (PONV), as well as chemotherapy-induced nausea and vomiting, has already been demonstrated in multiple clinical studies. The purpose of this study was to determine whether continuous infusion of palonosetron following single injection could reduce PONV to a greater extent than single injection only of palonosetron.
In total, 132 women were enrolled in the study. All subjects were over the age of 20 years and were scheduled to undergo gynecologic laparoscopic surgery. Patients were randomly allocated into two groups. In both groups, patients received 0.075 mg of palonosetron intravenously, immediately before induction of anesthesia. In the continuous palonosetron infusion group, 0.075 mg (1.5 ml) of palonosetron was added to the patient-controlled analgesia device. In the single-injection palonosetron group, 1.5 ml of normal saline was added.
The incidence of PONV 24 hours postoperatively was significantly lower in the continuous palonosetron infusion group than the single-injection palonosetron group (31.8 vs. 56.1%, P = 0.009).
Continuous palonosetron infusion, following single injection, reduces the incidence of PONV compared with single injection only.
帕洛诺司琼在预防术后恶心呕吐（PONV）以及化疗引起的恶心呕吐方面的疗效已在多项临床研究中得到证实。本研究的目的是确定单次注射后持续输注帕洛诺司琼是否比仅单次注射帕洛诺司琼能更大程度地降低PONV的发生率。
共有132名女性纳入本研究。所有受试者年龄均超过20岁，计划接受妇科腹腔镜手术。患者被随机分为两组。两组患者在麻醉诱导前即刻均静脉注射0.075 mg帕洛诺司琼。在帕洛诺司琼持续输注组，将0.075 mg（1.5 ml）帕洛诺司琼加入患者自控镇痛装置中。在帕洛诺司琼单次注射组，加入1.5 ml生理盐水。
帕洛诺司琼持续输注组术后24小时PONV的发生率显著低于帕洛诺司琼单次注射组（31.8%对56.1%，P = 0.009）。
与仅单次注射相比，单次注射后持续输注帕洛诺司琼可降低PONV的发生率。
