Eftekhar Behrooz, Moghimipour Eskandar, Eini Ebrahim, Jafarzadeh Mansour, Behrooz Narges
Department of Endodontics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran.
Jundishapur J Nat Pharm Prod. 2014 Jun 14;9(3):e14029. doi: 10.17795/jjnpp-14029. eCollection 2014 Aug.
Intra canal medicaments are used to reduce the number of bacteria and reinfection in endodontic procedures. Calcium Hydroxide was introduced to endodontics by Herman as an intracanal antimicrobial agent.
The aim of this study was to present an injectable formulation of calcium hydroxide then compare the final pH of this new formulation with Metapaste and evaluate the effect of a mixture of Calcium Hydroxide powder with water on human extracted teeth.
A total of 49 extracted human single-canal roots without caries and visible microcracks were included in this study. The teeth were decoronated and length of teeth was measured 1 mm anatomic apex. The canals were prepared using step-back technique. A cavity was created in the middle third of the buccal surface of all roots. The teeth were randomly divided into five groups: Group A (n = 15): In this group the root canals were filled with a mixture of calcium hydroxide powder and distilled water. Group B (n = 15): Included roots that were filled with Metapaste. Group C (n = 15): Root canals of this group were filled with new formulation of calcium hydroxide paste. Group D (negative control, n = 2): Included roots that were filled with a mixture of calcium hydroxide powder and distilled water. Group E (positive control, n = 2): Root canals of this group were filled with a mixture of calcium hydroxide powder and distilled water. Each tooth was immersed in a separate closed container with 4 mL saline for 2 weeks, pH of liquids were measured with an electrical pH meter after 7 and 14 days. The SPSS software (version 13) was used for data analysis. Analysis of variance (ANOVA) and Tukey tests were used for the statistical evaluation of results.
There was no significant difference at 7th day between the groups (P = 0.17) but at 14th day, a significant difference was observed between the groups (P = 0.04).
The new formulation of calcium hydroxide with methylcellulose base has slower ionic dissolution, more durability and longevity of alkaline properties in comparison to combination of powder with distilled water and is comparable with other commercial products.
根管内药物用于减少牙髓治疗过程中的细菌数量和再感染。氢氧化钙由赫尔曼引入牙髓病学作为一种根管内抗菌剂。
本研究的目的是提出一种可注射的氢氧化钙制剂，然后将这种新制剂的最终pH值与Metapaste进行比较，并评估氢氧化钙粉末与水的混合物对人离体牙的影响。
本研究共纳入49颗无龋且无可见微裂纹的人单根管离体牙。将牙齿去冠，并在解剖根尖1mm处测量牙齿长度。采用逐步后退技术预备根管。在所有牙根颊面的中三分之一处制备一个洞。将牙齿随机分为五组：A组（n = 15）：该组根管内填充氢氧化钙粉末和蒸馏水的混合物。B组（n = 15）：包括填充Metapaste的牙根。C组（n = 15）：该组根管内填充新的氢氧化钙糊剂制剂。D组（阴性对照，n = 2）：包括填充氢氧化钙粉末和蒸馏水混合物的牙根。E组（阳性对照，n = 2）：该组根管内填充氢氧化钙粉末和蒸馏水的混合物。将每颗牙齿浸泡在一个单独的装有4 mL生理盐水的密闭容器中2周，在第7天和第14天后用电子pH计测量液体的pH值。使用SPSS软件（版本13）进行数据分析。采用方差分析（ANOVA）和Tukey检验对结果进行统计学评估。
第7天时各组之间无显著差异（P = 0.17），但在第14天时，各组之间观察到显著差异（P = 0.04）。
与粉末与蒸馏水的组合相比，含甲基纤维素基的新型氢氧化钙制剂离子溶解较慢，碱性性质的耐久性和寿命更长，且与其他商业产品相当。
