Passàli D, Bellussi L, Ciferri G, Scaricabarozzi I
Clin Ter. 1989 Jan 31;128(2):105-11.
In a controlled clinical study of 40 patients, aged 18 to 65, suffering from acute inflammatory pathology of the upper respiratory tract or from a chronic form flaring into acute crisis, without any general symptoms of infection, were assigned at random to treatment with nimesulide in tablet form (100 mg x 2/day), or with phenylprenazone in capsules (200 mg x 2/day) for a period of seven days. In both groups a clinically significant reduction of the symptoms was obtained (congestion and edema of the pharyngeal mucosa, cough) as well as an improvement in the values of conductance and MCTt. Epigastralgy was evidenced in three subjects treated with nimesulide and in four treated with phenylprenazone. No significant variations of the laboratory parameters were found in either treatment group.
在一项针对40名年龄在18至65岁之间、患有上呼吸道急性炎症性病变或慢性炎症急性发作且无任何感染全身症状的患者的对照临床研究中，将他们随机分为两组，一组服用片剂形式的尼美舒利（100毫克×每日2次），另一组服用胶囊形式的非普拉宗（200毫克×每日2次），为期7天。两组患者的症状均在临床上得到了显著减轻（咽黏膜充血和水肿、咳嗽），并且传导率和MCTt值也有所改善。服用尼美舒利的3名受试者和服用非普拉宗的4名受试者出现了上腹部疼痛。两个治疗组的实验室参数均未发现显著变化。
