心房肽对普通章鱼离体体心脏的变时性和变力性作用。

Chronotropic and inotropic effects of atrial peptides on the isolated systemic heart of Octopus vulgaris.

作者信息

Agnisolo C, Cariello L, De Santis A, Miralto A, Tota B

机构信息

Dipartimento di Fisiologia Generale ed Ambientale, Università di Napoli, Italy.

出版信息

J Comp Physiol B. 1989;158(6):637-41. doi: 10.1007/BF00693001.

DOI:10.1007/BF00693001

PMID:2523916

Abstract

The chronotropic and inotropic effects of four atrial peptides (cardiodilatin 1-16, atrial natriuretic factor 8-33 and atriopeptin I and III) on the isolated systemic heart of Octopus vulgaris were studied. Using a preparation that produces a physiological stroke volume at physiological input pressures, it was found that ANF, atriopeptin I and atriopeptin III exerted both negative chronotropic and inotropic effects. In contrast, cardiodilatin produced a positive inotropic effect. A dose-response curve of ANF is reported, showing a threshold concentration of about 10(-12) M. The pharmacological and physiological implications of these results are discussed in relation to some characteristics of the cephalopod systemic heart.

摘要

研究了四种心房肽（心钠素1 - 16、心房利钠因子8 - 33以及心房肽I和III）对普通章鱼离体体循环心脏的变时和变力作用。使用一种在生理输入压力下能产生生理搏出量的标本，发现心房利钠因子、心房肽I和心房肽III均产生负性变时和变力作用。相比之下，心钠素产生正性变力作用。报道了心房利钠因子的剂量 - 反应曲线，显示阈值浓度约为10(-12) M。结合头足类动物体循环心脏的一些特征，讨论了这些结果的药理学和生理学意义。