Lambert C, Ribuot C, Robichaud A, Cusson J R
Research Centre, Hôpital du Sacré-Coeur de Montréal, Qué., Canada.
Eur J Pharmacol. 1994 Feb 11;252(3):245-52. doi: 10.1016/0014-2999(94)90169-4.
The effects of atrial natriuretic peptide (ANP) on heart rate and on the chronotropic response induced by angiotensin II were evaluated. The action of angiotensin II, injected into the sinus node artery, on heart rate was determined in anaesthetized and vagotomized dogs pretreated with beta-adrenoceptor antagonist (n = 9), before and after the infusion of physiological and pharmacological doses (10 and 50 ng/kg per min) of ANP. ANP plasma concentrations were determined by radioimmunoassay. Compared to the baseline concentration values (117 +/- 3 pg/ml), a slight increase was produced by the lower dose (293 +/- 45 pg/ml), whereas a significant augmentation was noted with the higher dose of ANP (1024 +/- 255 pg/ml). The basal heart rate and mean systemic arterial pressure were decreased (26.3 and 13.5%) during the intravenous infusion of the physiological dose of the peptide and were significantly reduced (32.5 and 29.2%, P < 0.05) by the administration of the pharmacological dose of ANP. Angiotensin II had a positive chronotropic effect (29 +/- 3 beats/min) that was significantly inhibited by the pharmacological dose of ANP. Our results suggest that ANP might have a role in the control of heart rate.
评估了心房利钠肽（ANP）对心率以及对血管紧张素II诱导的变时反应的影响。在用β-肾上腺素能受体拮抗剂预处理的麻醉和迷走神经切断的犬（n = 9）中，在输注生理剂量和药理剂量（每分钟10和50 ng/kg）的ANP之前和之后，测定注入窦房结动脉的血管紧张素II对心率的作用。通过放射免疫测定法测定ANP血浆浓度。与基线浓度值（117±3 pg/ml）相比，较低剂量产生了轻微增加（293±45 pg/ml），而较高剂量的ANP则出现了显著升高（1024±255 pg/ml）。在静脉输注该肽的生理剂量期间，基础心率和平均体动脉压降低（分别为26.3%和13.5%），而给予药理剂量的ANP使其显著降低（分别为32.5%和29.2%，P<0.05）。血管紧张素II具有正性变时作用（29±3次/分钟），该作用被药理剂量的ANP显著抑制。我们的结果表明，ANP可能在心率控制中起作用。
