Dennis Brittany Burns, Naji Leen, Bawor Monica, Bonner Ashley, Varenbut Michael, Daiter Jeff, Plater Carolyn, Pare Guillaume, Marsh David C, Worster Andrew, Desai Dipika, Samaan Zainab, Thabane Lehana
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada.
Syst Rev. 2014 Sep 19;3:105. doi: 10.1186/2046-4053-3-105.
Opioids are psychoactive analgesic drugs prescribed for pain relief and palliative care. Due to their addictive potential, effort and vigilance in controlling prescriptions is needed to avoid misuse and dependence. Despite the effort, the prevalence of opioid use disorder continues to rise. Opioid substitution therapies are commonly used to treat opioid dependence; however, there is minimal consensus as to which therapy is most effective. Available treatments include methadone, heroin, buprenorphine, as well as naltrexone. This systematic review aims to assess and compare the effect of all available opioid substitution therapies on the treatment of opioid dependence.
METHODS/DESIGN: The authors will search Medline, EMBASE, PubMed, PsycINFO, Web of Science, Cochrane Library, Cochrane Clinical Trials Registry, World Health Organization International Clinical Trials Registry Platform Search Portal, and the National Institutes for Health Clinical Trials Registry. The title, abstract, and full-text screening will be completed in duplicate. When appropriate, multiple treatment comparison Bayesian meta-analytic methods will be performed to deduce summary statistics estimating the effectiveness of all opioid substitution therapies in terms of retention and response to treatment (as measured through continued opioid abuse).
Using evidence gained from this systematic review, we anticipate disseminating an objective review of the current available literature on the effectiveness of all opioid substitution therapies for the treatment of opioid use disorder. The results of this systematic review are imperative to the further enhancement of clinical practice in addiction medicine.
PROSPERO CRD42013006507.
阿片类药物是用于缓解疼痛和姑息治疗的精神活性镇痛药。由于其成瘾潜力,需要努力并保持警惕来控制处方,以避免滥用和依赖。尽管做出了努力,但阿片类药物使用障碍的患病率仍在持续上升。阿片类药物替代疗法常用于治疗阿片类药物依赖;然而,对于哪种疗法最有效,几乎没有共识。现有的治疗方法包括美沙酮、海洛因、丁丙诺啡以及纳曲酮。本系统评价旨在评估和比较所有可用的阿片类药物替代疗法对阿片类药物依赖治疗的效果。
方法/设计:作者将检索Medline、EMBASE、PubMed、PsycINFO、科学引文索引、考克兰图书馆、考克兰临床试验注册库、世界卫生组织国际临床试验注册平台搜索门户以及美国国立卫生研究院临床试验注册库。标题、摘要和全文筛选将由两人独立完成。在适当的时候,将采用多种治疗比较贝叶斯荟萃分析方法来推导汇总统计数据,以估计所有阿片类药物替代疗法在治疗保留率和反应(通过持续存在的阿片类药物滥用情况衡量)方面的有效性。
利用从本系统评价中获得的证据,我们期望对当前关于所有阿片类药物替代疗法治疗阿片类药物使用障碍有效性的现有文献进行客观综述。本系统评价的结果对于进一步改善成瘾医学的临床实践至关重要。
PROSPERO CRD42013006507。