Villalba María, Santiago Isabel, Gómez de Segura Ignacio A
Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Complutense, Avda. Puerta de Hierro s/n 28040, Madrid, Spain.
Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University Complutense, Avda. Puerta de Hierro s/n 28040, Madrid, Spain.
Vet J. 2014 Nov;202(2):329-33. doi: 10.1016/j.tvjl.2014.08.007. Epub 2014 Aug 25.
The aim of this investigation was to determine the isoflurane-sparing effect and impact on arterial blood pressure and anaesthetic recovery of a constant rate infusion of medetomidine-propofol in horses. In a prospective, crossover, randomised study, six healthy horses (mean ± SD age, 13.7 ± 7.7 years; weight, 433 ± 51 kg) were anaesthetised twice with isoflurane and were randomly assigned to receive one of two treatments on each occasion, at least 2 weeks apart. The first treatment was saline (CTL group) and the second a medetomidine-propofol infusion (MP group; 1.25 µg/kg/h medetomidine and 3 mg/kg/h propofol). The isoflurane minimum alveolar concentration (MAC) was determined and the reduction in anaesthetic requirements was calculated. Cardiopulmonary data were recorded at different intervals during the procedure and anaesthetic recovery was blindly assessed using three independent scales. The MAC in the MP group (0.43 ± 0.08%) was 65% lower than in the CTL group (1.23 ± 0.10%). The MP group had a higher mean arterial blood pressure and required less dobutamine than the CTL group. The recovery quality in both groups was considered fair or good and an improvement was observed using the Donaldson scale in the MP group. The administration of a medetomidine-propofol constant rate infusion reduced anaesthetic isoflurane requirements to a clinically significant extent and improved stability of arterial blood pressure together with a good quality recovery. This regime could be useful for providing balanced anaesthesia in horses.
本研究的目的是确定在马中持续输注美托咪定-丙泊酚对异氟烷的节省效应及其对动脉血压和麻醉恢复的影响。在一项前瞻性、交叉、随机研究中，6匹健康马（平均±标准差年龄，13.7±7.7岁；体重，433±51 kg）用异氟烷进行了两次麻醉，并在每次麻醉时随机分配接受两种治疗之一，每次治疗间隔至少2周。第一种治疗是生理盐水（CTL组），第二种是美托咪定-丙泊酚输注（MP组；美托咪定1.25μg/kg/h和丙泊酚3mg/kg/h）。测定异氟烷最低肺泡浓度（MAC）并计算麻醉需求的降低情况。在手术过程中的不同时间间隔记录心肺数据，并使用三个独立的量表对麻醉恢复情况进行盲法评估。MP组的MAC（0.43±0.08%）比CTL组（1.23±0.10%）低65%。MP组的平均动脉血压较高，多巴酚丁胺的需求量比CTL组少。两组的恢复质量均被认为是中等或良好，并且在MP组中使用唐纳森量表观察到有所改善。持续输注美托咪定-丙泊酚在临床上显著降低了异氟烷的麻醉需求，改善了动脉血压的稳定性，并具有良好的恢复质量。这种方案可能有助于为马提供平衡麻醉。
