Song Qingkun, Zhao Lin, Li Jun, Ren Jun
Beijing Key Laboratory of Cancer Therapeutic Vaccine, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Beijing, China.
Xuanwu Hospital, Capital Medical University, Beijing, China.
Asia Pac J Public Health. 2015 May;27(4):469-75. doi: 10.1177/1010539514551199. Epub 2014 Sep 19.
This study aimed to investigate the contribution of fruit and family history to esophageal cancer, among residents with abnormal esophagus discovered in screening. The study was a frequency-matched case-control design in groups of normal esophagus, abnormal esophagus but not carcinoma, and esophageal squamous cell carcinoma. Odds ratio (OR) was estimated by unconditional logistic regression. Fruit intake (OR = 0.19, 95% CI = 0.06-0.56) and positive family history of esophageal cancer (OR = 3.87, 95% CI = 1.41-10.63) were associated with esophageal cancer compared to individuals with abnormal conditions of the esophagus. In individuals who consumed fruits at least once per week, the OR for family cancer history is reduced to a nonsignificant level (OR = 1.06, 95% CI = 0.07-15.91). In the individuals with abnormal esophagus at screening, fruit intake was possibly protective against esophageal cancer, even in the ones with positive family history. Local public health strategies should focus on the improvement in fruit intake.
本研究旨在调查在筛查中发现食管异常的居民中，水果摄入和家族史对食管癌的影响。该研究采用频率匹配的病例对照设计，分为食管正常组、食管异常但无癌症组和食管鳞状细胞癌组。通过无条件逻辑回归估计比值比（OR）。与食管有异常情况的个体相比，水果摄入量（OR = 0.19，95%CI = 0.06 - 0.56）和食管癌家族史阳性（OR = 3.87，95%CI = 1.41 - 10.63）与食管癌相关。在每周至少食用一次水果的个体中，家族癌症史的OR降至无统计学意义水平（OR = 1.06，95%CI = 0.07 - 15.91）。在筛查中食管异常的个体中，即使是有家族史阳性的个体，水果摄入也可能对食管癌有保护作用。当地公共卫生策略应侧重于提高水果摄入量。
