花生摄入与食管鳞癌风险降低相关：中国高危地区的病例对照研究。
Peanut consumption associated with a reduced risk of esophageal squamous cell carcinoma: A case-control study in a high-risk area in China.
机构信息
Department of Medical Oncology, Beijing Shijitan Hospital, Capital Medical University, The Ninth Academic Hospital of Peking University, Beijing, China.
Department of Medical Records and Statistics, Xuanwu Hospital, Capital Medical University, Beijing, China.
出版信息
Thorac Cancer. 2018 Jan;9(1):30-36. doi: 10.1111/1759-7714.12520. Epub 2017 Oct 4.
BACKGROUND
Esophageal cancer (EC) is ranked as the top 10th malignancy in China; however, an association between peanut consumption and EC risk has not yet been identified. This study explored the protective effects of peanut consumption against the risk of developing esophageal squamous cell carcinoma (ESCC) in a high-risk area.
METHODS
A case-control design was applied, with frequency matching by age and gender. A logistic regression model was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Two hundred and twenty-two cases and 222 controls were recruited from Yanting County from 2011 to 2012.
RESULTS
Peanut consumption 1-3 times per week reduced cancer risk by 38% (OR 0.62, 95% CI 0.34-1.13), while consumption ≥ 4 times per week reduced the risk by 70% (OR 0.31, 95% CI 0.16-0.59). A significant association was observed among individuals with negative family EC history (OR 0.25, 95% CI 0.12-0.49).
CONCLUSION
Peanut consumption may act as a protector against the occurrence of ESCC in high-risk areas, thus production and consumption should be promoted in high-risk areas in order to reduce the ESCC burden.
背景
食管癌（EC）在中国恶性肿瘤中排名第 10 位；然而，花生的消费与 EC 风险之间的关联尚未确定。本研究探讨了花生消费对高发地区食管鳞癌（ESCC）发病风险的保护作用。
方法
采用病例对照设计，按年龄和性别进行频数匹配。使用逻辑回归模型估计比值比（OR）和 95%置信区间（CI）。2011 年至 2012 年，在盐亭县招募了 222 例病例和 222 例对照。
结果
每周食用花生 1-3 次可降低 38%的癌症风险（OR 0.62，95%CI 0.34-1.13），每周食用花生≥4 次可降低 70%的风险（OR 0.31，95%CI 0.16-0.59）。在有食管癌家族史阴性的个体中观察到显著的相关性（OR 0.25，95%CI 0.12-0.49）。
结论
花生的消费可能是高发地区 ESCC 发生的保护因素，因此应在高发地区推广花生的生产和消费，以降低 ESCC 的负担。
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