Holoshitz J, Koning F, Coligan J E, De Bruyn J, Strober S
Department of Medicine, Stanford University, California 94305.
Nature. 1989 May 18;339(6221):226-9. doi: 10.1038/339226a0.
The majority of peripheral T cells express a heterodimeric, alpha/beta T-cell receptor, which recognizes specific antigenic peptides bound to self major histocompatibility complex (MHC) molecules, and either the CD4 or CD8 surface markers. An additional subset of T cells, whose physiological function is unknown, express a distinct CD3-associated receptor composed of gamma and delta chains. This subset includes cells lacking both CD4 and CD8 surface markers, which may be involved in autoimmunity. The recognition specificity of the gamma/delta receptors is not well characterized and has been defined in only one case to date, a murine cell line which shows MHC-linked specificity. In this report, we describe the isolation of CD4- CD8-, gamma/delta TCR bearing T cell clones from the synovial fluid of a rheumatoid arthritis patient. These T cell clones respond specifically to mycobacterial antigens without MHC restriction.
大多数外周T细胞表达一种异二聚体α/β T细胞受体，该受体识别与自身主要组织相容性复合体（MHC）分子结合的特定抗原肽，以及CD4或CD8表面标志物。另外还有一部分T细胞，其生理功能尚不清楚，它们表达一种由γ链和δ链组成的独特的与CD3相关的受体。这一亚群包括缺乏CD4和CD8表面标志物的细胞，可能与自身免疫有关。γ/δ受体的识别特异性尚未得到很好的表征，迄今为止仅在一个案例中得到定义，即一个显示MHC连锁特异性的小鼠细胞系。在本报告中，我们描述了从一名类风湿性关节炎患者的滑液中分离出携带γ/δ TCR的CD4-CD8-T细胞克隆。这些T细胞克隆对分枝杆菌抗原有特异性反应，且不受MHC限制。
