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碘-125近距离放射治疗儿童腮腺上皮-肌上皮癌一例

Iodine-125 brachytherapy for the treatment of a large parotid epithelial-myoepithelial carcinoma in a child.

作者信息

Zhang J, Zhen L, Zhang J G, Yu G Y

机构信息

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China.

出版信息

Int J Oral Maxillofac Surg. 2014 Dec;43(12):1431-5. doi: 10.1016/j.ijom.2014.08.007. Epub 2014 Sep 16.

Abstract

Epithelial-myoepithelial carcinoma (EMC) in the salivary glands is rare. Tumours originating from salivary glands are also rare in children. Radical resection is the main treatment used for EMC in salivary glands. However, this surgery is commonly associated with functional and/or cosmetic deficits. There is also a high percentage of local recurrence after a tumourectomy. We present a typical case of recurrent EMC in the left parotid gland of an 8-year-old girl. The patient was treated with iodine-125 brachytherapy. At the 2-month follow-up, the tumour size was reduced by 80%, and at 1 year, no tumour tissue was detected on positron emission tomography/computed tomography. At the 6-year follow-up, no local recurrence or distant metastasis was found and no complications had occurred. Iodine-125 brachytherapy is a potentially appropriate alternative treatment for EMC in the salivary glands, especially for paediatric patients.

摘要

涎腺上皮-肌上皮癌(EMC)较为罕见。涎腺来源的肿瘤在儿童中也很罕见。根治性切除是涎腺EMC的主要治疗方法。然而,这种手术通常会导致功能和/或美容缺陷。肿瘤切除术后局部复发率也很高。我们报告一例8岁女孩左腮腺复发性EMC的典型病例。该患者接受了碘-125近距离放射治疗。在2个月的随访中,肿瘤大小缩小了80%,1年后,正电子发射断层扫描/计算机断层扫描未检测到肿瘤组织。在6年的随访中,未发现局部复发或远处转移,也未发生并发症。碘-125近距离放射治疗是涎腺EMC潜在的合适替代治疗方法,尤其是对于儿科患者。

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