EGF 受体和其他受体酪氨酸激酶调控的新观点。
Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases.
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA; California Institute for Quantitative Biosciences, University of California, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA; Department of Chemistry, University of California, Berkeley, CA 94720, USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
出版信息
Trends Biochem Sci. 2014 Oct;39(10):437-46. doi: 10.1016/j.tibs.2014.08.001. Epub 2014 Sep 18.
The activation of receptor tyrosine kinases in response to extracellular signals is a principal component of metazoan signaling. Structural analysis of the extracellular and intracellular domains of these receptors has shed substantial light on the mechanisms underlying their activation. A remaining challenge is to understand how these domains operate together in the context of the full-length receptors. With a focus on the epidermal growth factor (EGF) receptor, this review highlights recent advances towards this goal. Although receptor tyrosine kinases are divergent in terms of the details of how they operate, these studies reveal common mechanisms that ensure activation in the proper context. Understanding these mechanisms provides insights into the vulnerabilities of these receptors to disease-causing mutations.
细胞外信号引发的受体酪氨酸激酶的激活是后生动物信号转导的主要组成部分。对这些受体的细胞外和细胞内结构域的结构分析为其激活机制提供了重要线索。目前仍面临的挑战是要理解这些结构域在全长受体中是如何共同发挥作用的。本文以表皮生长因子（EGF）受体为例，重点介绍了实现这一目标的最新进展。尽管受体酪氨酸激酶在其作用细节上存在差异，但这些研究揭示了确保在适当环境下激活的共同机制。了解这些机制为这些受体对致病突变的易感性提供了深入的认识。
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