Chrcanovic Bruno Ramos, Albrektsson Tomas, Wennerberg Ann
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
Department of Biomaterials, Göteborg University, Göteborg, Sweden.
Head Neck. 2016 Mar;38(3):448-81. doi: 10.1002/hed.23875. Epub 2015 Jun 16.
The purpose of the present meta-analysis was to test the null hypothesis of no difference in dental implant failure rates, postoperative infection, and marginal bone loss for patients being rehabilitated by dental implants and being previously irradiated in the head and neck region versus nonirradiated patients against the alternative hypothesis of a difference. The study suggests that irradiation negatively affects the survival of implants, as well as the difference in implant location (maxilla vs mandible), but there is no statistically significant difference in survival when implants are inserted before or after 12 months after radiotherapy. The study failed to support the effectiveness of hyperbaric oxygen therapy in irradiated patients. It was observed that there was a tendency of lower survival rates of implants inserted in the patients submitted to higher irradiation doses. The results should be interpreted with caution because of the presence of uncontrolled confounding factors in the included studies.
本荟萃分析的目的是检验零假设,即接受牙种植体修复且先前接受过头颈部放疗的患者与未接受放疗的患者在牙种植体失败率、术后感染和边缘骨丢失方面无差异,备择假设为存在差异。该研究表明,放疗会对种植体的存活产生负面影响,以及种植体位置(上颌骨与下颌骨)的差异,但在放疗后12个月之前或之后植入种植体时,其存活率在统计学上没有显著差异。该研究未能支持高压氧治疗在接受放疗患者中的有效性。据观察,接受较高放疗剂量的患者植入的种植体存活率有降低的趋势。由于纳入研究中存在未控制的混杂因素,对结果的解释应谨慎。