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在血管成形术失败、溶栓后以及急性心肌梗死时进行的急诊冠状动脉搭桥术,与术前心源性休克无关。

Emergency coronary bypass not associated with preoperative cardiogenic shock in failed angioplasty, after thrombolysis, and for acute myocardial infarction.

作者信息

Barner H B, Lea J W, Naunheim K S, Stoney W S

机构信息

Department of Surgery, St. Louis University Medical Center, Missouri.

出版信息

Circulation. 1989 Jun;79(6 Pt 2):I152-9.

PMID:2524296
Abstract

We have reviewed the literature and supplemented it with our own experience to provide a current viewpoint on emergency coronary bypass in three settings in which cardiogenic shock did not exist preoperatively. Acute failure of coronary angioplasty led to emergency operation in 701 patients with 25 (3.6%) deaths. There was a 37.6% incidence of perioperative infarction. Thrombolytic therapy for acute myocardial infarction, sometimes followed by angioplasty, led to emergency operation within 8 hours in 145 instances with four (2.1%) deaths. Emergency coronary bypass was primary therapy for 1,051 patients with acute myocardial infarction with 51 (4.9%) hospital deaths. Emergency operation for failed angioplasty is frequently mandated in the setting of surgical standby and iatrogenic ischemia although some operations could be postponed to an elective status. Emergency operation after thrombolytic therapy has been used for unsuccessful angioplasty of the infarct vessel, left main stenosis of greater than 50%, left main equivalent, multivessel disease with complex lesions not amenable to angioplasty, or failure to restore patency of the infarct vessel with thrombolysis. Operation within 12 hours of thrombolytic therapy is associated with a coagulopathy causing increased bleeding, the need for transfusion, and a greater incidence of reoperation for perioperative bleeding.

摘要

我们回顾了相关文献,并结合自身经验,就术前不存在心源性休克的三种情况下的急诊冠状动脉搭桥术提供当前观点。701例因冠状动脉血管成形术急性失败而接受急诊手术的患者中,有25例(3.6%)死亡。围手术期梗死发生率为37.6%。急性心肌梗死的溶栓治疗,有时随后进行血管成形术,导致145例在8小时内接受急诊手术,其中4例(2.1%)死亡。急诊冠状动脉搭桥术是1051例急性心肌梗死患者的主要治疗方法,住院死亡51例(4.9%)。尽管有些手术可以推迟到择期进行,但在手术待命和医源性缺血的情况下,血管成形术失败后的急诊手术经常是必要的。溶栓治疗后急诊手术用于梗死血管血管成形术失败、左主干狭窄大于50%、左主干等同病变、多支血管病变且病变复杂不适于血管成形术,或溶栓未能恢复梗死血管通畅的情况。溶栓治疗后12小时内进行手术与凝血病有关,会导致出血增加、需要输血,以及围手术期出血再次手术的发生率更高。

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