巴西成人健康纵向研究（ELSA-Brasil）中的颈动脉内膜中层厚度值分布情况。
Carotid intima-media thickness value distributions in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
作者信息
Santos Itamar S, Bittencourt Márcio S, Oliveira Ilka R S, Souza Angelita G, Meireles Danilo P, Rundek Tatjana, Foppa Murilo, Bezerra Daniel C, Freire Cláudia M V, Roelke Leonard H, Carrilho Sayonara, Benseñor Isabela M, Lotufo Paulo A
机构信息
Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, São Paulo, Brazil.
Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, São Paulo, Brazil.
出版信息
Atherosclerosis. 2014 Nov;237(1):227-35. doi: 10.1016/j.atherosclerosis.2014.09.004. Epub 2014 Sep 9.
OBJECTIVE
Carotid intima-media thickness (IMT) is a noninvasive measurement of early atherosclerosis. Most IMT studies have involved populations with low rates of racial blending. The aim of the present article is to describe IMT value distributions and analyze the influence of sex and race on IMT values in a large Brazilian sample, a setting with a high rate of racial admixture.
METHODS
The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a multicenter cohort of 15,105 adult (aged 35-74 years) civil servants in six Brazilian cities. Baseline assessment included IMT measurements in both common carotid arteries. Race was self-reported. We studied the association between sex and race with IMT values using multiple linear regression models. We conducted analyses in all and low-risk individuals, defined as those without classical cardiovascular risk factors.
RESULTS
We analyzed complete IMT data from 10,405 ELSA-Brasil participants. We present nomograms by age for all and low-risk individuals, stratified by sex and race. We found that men had significantly higher maximal IMT values compared with women (β = 0.058; P < 0.001). This association remained for low-risk individuals (β = 0.027; P = 0.001). In addition, Brown and White individuals had lower maximal IMT values compared with Black individuals for all (β = -0.034 and β = -0.054, respectively; P < 0.001) and low-risk individuals (β = -0.027; P = 0.013 and β = -0.035; P < 0.001, respectively).
CONCLUSION
We found significantly higher IMT values in men. We found significantly higher IMT values in Black individuals than White and Brown individuals. These results persisted when analyses were restricted to low-risk individuals.
目的
颈动脉内膜中层厚度（IMT）是早期动脉粥样硬化的一种非侵入性测量方法。大多数IMT研究涉及种族融合率较低的人群。本文的目的是描述在巴西一个种族混合率较高的大样本中IMT值的分布情况，并分析性别和种族对IMT值的影响。
方法
巴西成人健康纵向研究（ELSA - Brasil）是一项多中心队列研究，涉及巴西六个城市的15105名年龄在35 - 74岁的成年公务员。基线评估包括双侧颈总动脉的IMT测量。种族由参与者自我报告。我们使用多元线性回归模型研究性别和种族与IMT值之间的关联。我们对所有个体以及定义为无经典心血管危险因素的低风险个体进行了分析。
结果
我们分析了来自10405名ELSA - Brasil参与者的完整IMT数据。我们给出了按年龄划分的所有个体和低风险个体的列线图，按性别和种族分层。我们发现，与女性相比，男性的最大IMT值显著更高（β = 0.058；P < 0.001）。这种关联在低风险个体中依然存在（β = 0.027；P = 0.001）。此外，对于所有个体（分别为β = -0.034和β = -0.054；P < 0.001）以及低风险个体（β = -0.027；P = 0.013和β = -0.035；P < 0.001），棕色人种和白人个体的最大IMT值低于黑人个体。
结论
我们发现男性的IMT值显著更高。我们发现黑人个体的IMT值显著高于白人和棕色人种个体。当分析仅限于低风险个体时，这些结果依然存在。
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