硫醇和硼氢化钠激活抗肿瘤抗生素新制癌菌素的机制。
Mechanism of activation of the antitumor antibiotic neocarzinostatin by mercaptan and sodium borohydride.
作者信息
Hensens O D, Goldberg I H
机构信息
Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.
出版信息
J Antibiot (Tokyo). 1989 May;42(5):761-8. doi: 10.7164/antibiotics.42.761.
PMID:2524463
Abstract
The structures of mercaptan and sodium borohydride reaction products of neocarzinostatin chromophore A (NCS Chrom A) are compared. Implications on the mechanism of activation of NCS are discussed.
摘要
比较了新制癌菌素生色团A（NCS Chrom A）的硫醇与硼氢化钠反应产物的结构。讨论了其对NCS活化机制的影响。
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