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硫醇和硼氢化钠激活抗肿瘤抗生素新制癌菌素的机制。

Mechanism of activation of the antitumor antibiotic neocarzinostatin by mercaptan and sodium borohydride.

作者信息

Hensens O D, Goldberg I H

机构信息

Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey 07065.

出版信息

J Antibiot (Tokyo). 1989 May;42(5):761-8. doi: 10.7164/antibiotics.42.761.

DOI:10.7164/antibiotics.42.761
PMID:2524463
Abstract

The structures of mercaptan and sodium borohydride reaction products of neocarzinostatin chromophore A (NCS Chrom A) are compared. Implications on the mechanism of activation of NCS are discussed.

摘要

比较了新制癌菌素生色团A（NCS Chrom A）的硫醇与硼氢化钠反应产物的结构。讨论了其对NCS活化机制的影响。

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Mechanism of activation of the antitumor antibiotic neocarzinostatin by mercaptan and sodium borohydride.硫醇和硼氢化钠激活抗肿瘤抗生素新制癌菌素的机制。
J Antibiot (Tokyo). 1989 May;42(5):761-8. doi: 10.7164/antibiotics.42.761.
2
Neocarzinostatin chromophore: presence of a highly strained ether ring and its reaction with mercaptan and sodium borohydride.新制癌菌素生色团：高度张力醚环的存在及其与硫醇和硼氢化钠的反应。
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Neocarzinostatin chromophore. Assignment of spectral properties and structural requirements for binding to DNA.新制癌菌素发色团。光谱性质的归属及与DNA结合的结构要求
Mol Pharmacol. 1983 Mar;23(2):500-10.
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Absolute configuration of the amino sugar moiety of the neocarzinostatin chromophore.新制癌菌素生色团氨基糖部分的绝对构型。
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Sites in the diyne-ene bicyclic core of neocarzinostatin chromophore responsible for hydrogen abstraction from DNA.新制癌菌素发色团二炔-烯双环核心中负责从DNA夺取氢的位点。
Biochemistry. 1988 Oct 18;27(21):8106-14. doi: 10.1021/bi00421a020.
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Induced formation of a DNA bulge structure by a molecular wedge ligand-postactivated neocarzinostatin chromophore.通过分子楔形配体后活化的新制癌菌素发色团诱导形成DNA凸起结构。
Biochemistry. 2002 Apr 23;41(16):5131-43. doi: 10.1021/bi012112o.
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New complex of post-activated neocarzinostatin chromophore with DNA: bulge DNA binding from the minor groove.新的后激活型制癌菌素发色团与DNA的复合物：从小沟结合凸起DNA
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Mode of reversible binding of neocarzinostatin chromophore to DNA: base sequence dependency of binding.新制癌菌素发色团与DNA的可逆结合模式：结合的碱基序列依赖性
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An antitumor polypeptide antibiotic neocarzinostatin: the mode of apo-protein--chromophore interaction.一种抗肿瘤多肽抗生素新制癌菌素：脱辅基蛋白-发色团相互作用模式
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Binding and cleavage characteristics of the complexes formed between the neocarzinostatin chromophore and single site containing oligonucleotides.
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Spontaneous generation of a biradical species of neocarzinostatin chromophore: role in DNA bulge-specific cleavage.新制癌菌素发色团双自由基物种的自发产生：在DNA凸起特异性切割中的作用。
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Molecular models of neocarzinostatin damage of DNA: analysis of sequence dependence in 5'GAGCG:5'CGCTC.新制癌菌素对DNA损伤的分子模型：5'GAGCG:5'CGCTC序列依赖性分析
Nucleic Acids Res. 1990 Apr 25;18(8):2093-9. doi: 10.1093/nar/18.8.2093.
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Selective abstraction of 2H from C-5' of thymidylate in an oligodeoxynucleotide by the radical center at C-6 of the diradical species of neocarzinostatin: chemical evidence for the structure of the activated drug-DNA complex.新制癌菌素双自由基物种中C-6位的自由基中心对寡脱氧核苷酸中胸苷酸C-5'位的2H进行选择性提取：活化药物-DNA复合物结构的化学证据。
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