新制癌菌素发色团与DNA的可逆结合模式：结合的碱基序列依赖性
Mode of reversible binding of neocarzinostatin chromophore to DNA: base sequence dependency of binding.
作者信息
Dasgupta D, Goldberg I H
出版信息
Nucleic Acids Res. 1986 Jan 24;14(2):1089-105. doi: 10.1093/nar/14.2.1089.
Abstract
The reversible binding of neocarzinostatin chromophore to polynucleotides was studied in order to understand the molecular basis of its base sequence-specificity in DNA damage production. Studies of the spectroscopic and thermodynamic properties of chromophore-polynucleotide interactions reveal that the binding of the chromophore to poly(dA-dT) is qualitatively and quantitatively different from that to poly(dG-dC) (and poly(dI-dC]. From these and other experiments using double-stranded mixtures of homopolynucleotides, it is proposed that the observed A T specific intercalation might result from differential recognition of minor variations in the B-DNA type structure by the chromophore.
摘要
为了理解新制癌菌素发色团在产生DNA损伤时碱基序列特异性的分子基础，研究了其与多核苷酸的可逆结合。对发色团 - 多核苷酸相互作用的光谱和热力学性质的研究表明，发色团与聚（dA - dT）的结合在性质和数量上与聚（dG - dC）（和聚（dI - dC））不同。从这些以及其他使用同聚核苷酸双链混合物的实验中，有人提出观察到的AT特异性嵌入可能是由于发色团对B - DNA型结构中微小变化的差异识别所致。
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