Gara Rishi K, Kumari Sonam, Ganju Aditya, Yallapu Murali M, Jaggi Meena, Chauhan Subhash C
Department of Pharmaceutical Sciences and Center for Cancer Research, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Department of Pharmaceutical Sciences and Center for Cancer Research, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Drug Discov Today. 2015 Jan;20(1):156-64. doi: 10.1016/j.drudis.2014.09.008. Epub 2014 Sep 20.
Axon guidance molecules, slit glycoprotein (Slit) and Roundabout receptor (Robo), have implications in the regulation of physiological processes. Recent studies indicate that Slit and Robo also have important roles in tumorigenesis, cancer progression and metastasis. The Slit/Robo pathway can be considered a master regulator for multiple oncogenic signaling pathways. Herein, we provide a comprehensive review on the role of these molecules and their associated signaling pathways in cancer progression and metastasis. Overall, the current available data suggest that the Slit/Robo pathway could be a promising target for development of anticancer drugs.
轴突导向分子、缝隙糖蛋白(Slit)和轮状蛋白受体(Robo)在生理过程的调节中具有重要作用。最近的研究表明,Slit和Robo在肿瘤发生、癌症进展和转移中也发挥着重要作用。Slit/Robo信号通路可被视为多种致癌信号通路的主要调节因子。在此,我们全面综述了这些分子及其相关信号通路在癌症进展和转移中的作用。总体而言,目前可得的数据表明,Slit/Robo信号通路可能是开发抗癌药物的一个有前景的靶点。