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近期急性心肌梗死后冠状动脉旁路移植术中术前主动脉内球囊反搏对术后结局影响的倾向匹配分析

Propensity-matched analysis of the effect of preoperative intraaortic balloon pump in coronary artery bypass grafting after recent acute myocardial infarction on postoperative outcomes.

作者信息

Yu Pey-Jen, Cassiere Hugh A, Dellis Sophia L, Kohn Nina, Manetta Frank, Hartman Alan R

出版信息

Crit Care. 2014 Sep 23;18(5):531. doi: 10.1186/s13054-014-0531-z.

DOI:10.1186/s13054-014-0531-z
PMID:25246161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4182781/
Abstract

INTRODUCTION

There is substantial variability in the preoperative use of intraaortic balloon pumps (IABPs) in patients undergoing coronary artery bypass grafting post myocardial infarction. The objective of this study is to determine the effect of preoperative IABPs on postsurgical outcomes in this subset of patients.

METHODS

From 2007 to 2012, 877 patients underwent isolated coronary artery bypass post myocardial infarction. Four hundred and six patients were propensity-score matched based on the likelihood of receiving a preoperative balloon pump. Total blood transfusion requirements, composite in-hospital morbidity and/or mortality end point, total hours in the intensive care unit, and length of hospital stay were compared between the two groups.

RESULTS

No significant differences in demographics, preoperative risk factors, intraoperative variables or length of hospital stay were found between patients with and without balloon pumps after propensity score matching. Compared to patients without balloon pumps, a higher percentage of patients with preoperative IABPs required transfusions. Patients with preoperative balloon pumps were more likely to have the composite end point of in-hospital morbidity (24.1% versus 12.8%, P <0.004), and increased hours in the intensive care unit (median hours: 69.0 versus 46.0, P <0.013) as compared to patients without balloon pumps.

CONCLUSIONS

The use of preoperative IABPs in patients undergoing isolated coronary artery bypass grafting after myocardial infarction is associated with increased transfusion requirements, increased in-hospital morbidity and longer postoperative intensive care unit stay as compared to patients without IABPs.

摘要

引言

在心肌梗死后接受冠状动脉搭桥手术的患者中,主动脉内球囊泵(IABP)的术前使用存在很大差异。本研究的目的是确定术前使用IABP对该亚组患者术后结局的影响。

方法

2007年至2012年,877例患者在心肌梗死后接受了单纯冠状动脉搭桥手术。根据接受术前球囊泵的可能性,对406例患者进行了倾向评分匹配。比较了两组患者的总输血需求量、院内综合发病率和/或死亡率终点、重症监护病房的总时长以及住院时间。

结果

倾向评分匹配后,使用和未使用球囊泵的患者在人口统计学、术前危险因素、术中变量或住院时间方面未发现显著差异。与未使用球囊泵的患者相比,术前使用IABP 的患者输血比例更高。与未使用球囊泵的患者相比,术前使用球囊泵的患者更有可能出现院内发病的综合终点(24.1% 对12.8%,P <0.004),并且重症监护病房的时长增加(中位时长:69.0对46.0,P <0.013)。

结论

与未使用IABP的患者相比,心肌梗死后接受单纯冠状动脉搭桥手术的患者术前使用IABP与输血需求增加、院内发病率增加以及术后重症监护病房停留时间延长有关。

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