老年人的药物负担指数：理论与实践问题
Drug Burden Index in older adults: theoretical and practical issues.
作者信息
Kouladjian Lisa, Gnjidic Danijela, Chen Timothy F, Mangoni Arduino A, Hilmer Sarah N
机构信息
Sydney Medical School, University of Sydney, Kolling Institute of Medical Research and Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, NSW, Australia.
Sydney Medical School, University of Sydney, Kolling Institute of Medical Research and Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital, NSW, Australia ; Faculty of Pharmacy, University of Sydney, Sydney, NSW, Australia.
出版信息
Clin Interv Aging. 2014 Sep 9;9:1503-15. doi: 10.2147/CIA.S66660. eCollection 2014.
Anticholinergic and sedative medications are commonly used in older adults and are associated with adverse clinical outcomes. The Drug Burden Index was developed to measure the cumulative exposure to these medications in older adults and its impact on physical and cognitive function. This narrative review discusses the research and clinical applications of the Drug Burden Index, and its advantages and limitations, compared with other pharmacologically developed measures of high-risk prescribing.
抗胆碱能药物和镇静药物常用于老年人，且与不良临床结局相关。药物负担指数旨在衡量老年人对这些药物的累积暴露情况及其对身体和认知功能的影响。本叙述性综述讨论了药物负担指数的研究和临床应用，以及与其他药理学上制定的高风险处方衡量指标相比，它的优势和局限性。
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