Asgharnia Maryam, Faraji Roya, Mirblouk Fariba, Atrkar Roshan Zahra, Parvizi Ayda
Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Guilan, Iran.
Department of Biostatistics, Guilan University of Medical Sciences, Guilan, Iran.
Iran J Reprod Med. 2012 Jul;10(4):303-6.
Vaginal sonograghy and serial -hCG are the most common diagnostic methods for ectopic pregnancy but about 50% of cases are initially misdiagnosed. In tubal pregnancy the zygote lies next to the muscular layer, and this invasion causes an increase in creatine phosphokinase (CPK) in blood.
assessment of CPK and its isoenzyme CPK-MB as a diagnostic marker for tubal pregnancy.
In this case-control study, 111 women between 16-40 years in first-trimester pregnancy admitted to emergency ward of Rasht Alzahra hospital with abdominal pain or vaginal bleeding were included and according to sonography and βhCG divided into 3 groups (N=37): tubal pregnancy (1), threatened abortion (2) and normal pregnancy (3). Blood samples were taken for totalCPK and CPK-MB before any invasive procedure.
Mean total CPK level were 96.27±63.9 u/lit (group 1), 55.37±14.1 u/lit (group 2) and 48.94±19.2 u/lit (group 3) and was significantly higher in tubal pregnancy compared to other groups. Mean CPK-MB levels in 3 groups were 15.62±5.2 u/lit, 17.32±6.9 u/lit, and 15.1±4.7 u/lit, respectively which was not significant.
It seems that determination of total CPK can enhance the diagnostic value of tubal pregnancy.
阴道超声检查和连续检测人绒毛膜促性腺激素（β-hCG）是诊断异位妊娠最常用的方法，但约50%的病例最初会被误诊。在输卵管妊娠中，受精卵位于肌层旁，这种侵入会导致血液中肌酸磷酸激酶（CPK）升高。
评估CPK及其同工酶CPK-MB作为输卵管妊娠诊断标志物的价值。
在这项病例对照研究中，纳入了111名年龄在16至40岁之间、孕早期因腹痛或阴道出血入住拉什特·阿尔扎赫拉医院急诊病房的孕妇，并根据超声检查和β-hCG分为3组（每组37例）：输卵管妊娠组（1组）、先兆流产组（2组）和正常妊娠组（3组）。在进行任何侵入性操作前采集血样检测总CPK和CPK-MB。
总CPK平均水平在输卵管妊娠组为96.27±63.9 U/L（1组），先兆流产组为55.37±14.1 U/L（2组），正常妊娠组为48.94±19.2 U/L（3组），输卵管妊娠组显著高于其他组。3组CPK-MB平均水平分别为15.62±5.2 U/L、17.32±6.9 U/L和15.1±4.7 U/L，差异无统计学意义。
似乎检测总CPK可提高输卵管妊娠的诊断价值。
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