Ghorbani Maryam, Keramat Afsaneh, Mohsenzadeh Ledari Farideh
Student Research Committee, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
Reproductive Studies and Women's Health Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
Arch Acad Emerg Med. 2020 Jan 11;8(1):e9. eCollection 2020.
Creatine phosphokinase (CPK) is an intracellular enzyme found in higher levels in the brain, myocardium, soft muscle and skeletal muscle, as well as the fallopian tube. This review was conducted to evaluate the role of serum CPK in early diagnosis of tubal ectopic pregnancy (EP).
We performed an electronic literature search in Web of Science, Scopus, Embase and Medline databases and manual search in Google scholar and evaluated papers from the beginning of 1990 to September 2018. The inclusion criteria consisted of cohort, case-control and diagnostic value studies in English or Persian. Two independent researchers used the inclusion and exclusion criteria. In cases where there was doubt about the eligibility of studies, this problem was resolved by consulting a third researcher. After a thorough search, finally, we found 27 papers. However, four of these articles did not have the inclusion criteria and we excluded them from the study. As a result, 24 studies were evaluated.
Most studies have approved the use of CPK measurements in EP diagnosis. The main variable measured in most studies was the mean total CPK level. However, there is limited knowledge about the efficacy of measuring CPK levels in EP diagnosis; this review of studies shows positive results regarding use of CPK in EP diagnosis.
The results highlighted the potential benefits of CPK as a marker for early diagnosis of EP.
肌酸磷酸激酶（CPK）是一种细胞内酶，在脑、心肌、平滑肌、骨骼肌以及输卵管中含量较高。本综述旨在评估血清CPK在输卵管异位妊娠（EP）早期诊断中的作用。
我们在科学网、Scopus、Embase和Medline数据库中进行了电子文献检索，并在谷歌学术中进行了手动检索，评估了1990年初至2018年9月的论文。纳入标准包括英文或波斯文的队列研究、病例对照研究和诊断价值研究。两名独立研究人员使用纳入和排除标准。在对研究的合格性存在疑问的情况下，通过咨询第三位研究人员解决该问题。经过全面检索，最终我们找到了27篇论文。然而，其中四篇文章不符合纳入标准，我们将它们排除在研究之外。结果，对24项研究进行了评估。
大多数研究认可CPK测量在EP诊断中的应用。大多数研究中测量的主要变量是CPK总水平均值。然而，关于测量CPK水平在EP诊断中的有效性的知识有限；本研究综述显示CPK在EP诊断中的应用取得了积极结果。
结果突出了CPK作为EP早期诊断标志物的潜在益处。
