Kappler J, Kotzin B, Herron L, Gelfand E W, Bigler R D, Boylston A, Carrel S, Posnett D N, Choi Y, Marrack P
Howard Hughes Medical Institute, Denver, CO.
Science. 1989 May 19;244(4906):811-3. doi: 10.1126/science.2524876.
The staphylococcal toxins are responsible for a number of diseases in man and other animals. Many of them have also long been known to be powerful T cell stimulants. They do not, however, stimulate all T cells. On the contrary, each toxin reacts with human T cells bearing particular V beta sequences as part of their receptors for major histocompatibility complex protein-associated antigen. The specificity of these toxins for V beta s puts them in the recently described class of superantigens and may account for the differential sensitivity of different individuals to the toxic effects of these proteins.
葡萄球菌毒素可引发人类和其他动物的多种疾病。长期以来，人们还知道其中许多毒素是强大的T细胞刺激剂。然而，它们并非刺激所有的T细胞。相反，每种毒素都与带有特定Vβ序列的人类T细胞发生反应，这些Vβ序列是其主要组织相容性复合体蛋白相关抗原受体的一部分。这些毒素对Vβ的特异性使其属于最近描述的超抗原类别，这可能解释了不同个体对这些蛋白质毒性作用的不同敏感性。
