[Guide values for 1-methyl-2-pyrrolidone in indoor air. Report of the German Ad-hoc Working Group on indoor Guidelines of the Indoor Air Hygiene Committee and of the States' Supreme Health Authorities].

The German Ad-hoc Working Group on Indoor Guidelines of the Indoor Air Hygiene Committee and the States' Supreme Health Authorities is issuing indoor air guide values to protect public health. No human studies of sufficient quality are available for health evaluation of 1-methyl-2-pyrrolidone in air. In a well-documented chronic inhalation toxicity study in rats significant impairment of weight gain development has been observed (LOAEC = 400 mg/m(3)). The Working Group used this LOAEC as the point of departure for the derivation of guide value II. The conversion of repeated inhalation to continuous exposure (6-24 h; 5-7 days) used a factor of 5.6. By applying an interspecies factor of 2.5 for toxicodynamics, a factor of 10 to account for individual differences and an additional factor of 2 to include sensitive subgroups, results in a health hazard guide value (RW II) of 1 mg 1-methyl-2-pyrrolidone/m(3) indoor air (rounded). By using the NOAEC of 40 mg/m(3) from the same study and applying the same assessment factors as above a precautionary guide value (RW I) of 0.1 mg 1-methyl-2-pyrrolidone/m(3) is calculated.