Hauglann Lisbeth, Handegaard Bjørn Helge, Ulvund Stein Erik, Nordhov Marianne, Rønning John A, Kaaresen Per Ivar
Division of Child and Adolescent Health, Department of Child and Adolescent Psychiatry, University Hospital of North Norway, Tromsø, Norway.
Regional Centre for Child and Youth Mental Health and Child Welfare, The Arctic University of Norway, Tromsø, Norway.
Arch Dis Child Fetal Neonatal Ed. 2015 Jan;100(1):F11-6. doi: 10.1136/archdischild-2014-306496. Epub 2014 Sep 23.
Examine the effect of an early intervention programme on cognitive outcome at 7 and 9 years in children with birth weight (BW) <2000 g.
A randomised controlled trial of a modified version of the Mother-Infant Transaction Program.
A single tertiary neonatal unit.
146 infants were randomised into a preterm control group (74) or a preterm intervention group (72).
The intervention consisted of eight sessions shortly before discharge and four home visits by specially trained nurses focusing on the infants' unique characteristics, temperament, developmental potential and the interaction between infants and parents.
Outcomes were assessed with the Wechsler Intelligence Scale for Children (WISC-III).
Mean BWs were 1396 (429) g in the intervention group and 1381(436) g in the control group. After adjusting for the possible clustering effects of twin pairs and maternal education, there were no significant differences in WISC-III scores at age 7 or 9. The mean difference was 4.1 points (95% CI -1.5 to 9.8 points) in favour of the intervention group at 7 years and 2.2 points (95% CI -3.4 to 7.6 points) at 9 years. At 7 years, a 6.8 points difference in the Verbal Comprehension Index (95% CI 0.5 to 13.0 points) was found in favour of the intervention group. Loss to follow-up at age 7 and 9 was 11% and 14%, respectively.
This intervention programme did not have a sustained significant effect on overall cognitive outcomes in preterm children at age 7 and 9.
The trial has been registered at http://www.clinicaltrials.gov (identifier NCT00222456).
研究早期干预项目对出生体重（BW）<2000g儿童7岁和9岁时认知结局的影响。
对母婴互动项目改良版进行的随机对照试验。
一家三级新生儿专科病房。
146名婴儿被随机分为早产对照组（74名）或早产干预组（72名）。
干预包括出院前不久的8次课程以及由经过专门培训的护士进行4次家访，重点关注婴儿的独特特征、气质、发育潜力以及婴儿与父母之间的互动。
采用韦氏儿童智力量表（WISC-III）评估结局。
干预组的平均出生体重为1396（429）g，对照组为1381（436）g。在调整双胞胎对和母亲教育可能产生的聚集效应后，7岁或9岁时WISC-III评分无显著差异。7岁时有利于干预组的平均差异为4.1分（95%CI -1.5至9.8分），9岁时为2.2分（95%CI -3.4至7.6分）。7岁时，言语理解指数有利于干预组的差异为6.8分（95%CI 0.5至13.0分）。7岁和9岁时的失访率分别为11%和14%。
该干预项目对7岁和9岁早产儿童的总体认知结局没有持续显著影响。
