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紧张性和相位性多巴胺动力学的共同作用。

The coaction of tonic and phasic dopamine dynamics.

作者信息

Atcherley Christopher W, Wood Kevin M, Parent Kate L, Hashemi Parastoo, Heien Michael L

机构信息

Department of Chemistry and Biochemistry, University of Arizona, 1306 East University Boulevard, Tucson, AZ 85721, USA.

出版信息

Chem Commun (Camb). 2015 Feb 11;51(12):2235-8. doi: 10.1039/c4cc06165a.

DOI:10.1039/c4cc06165a
PMID:25249291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4825181/
Abstract

Tonic neurochemical dopamine activity underlies many brain functions; however a consensus on this important concentration has not yet been reached. In this work, we introduce in vivo fast-scan controlled-adsorption voltammetry to report tonic dopamine concentrations (90 ± 9 nM) and the dopamine diffusion coefficient (1.05 ± 0.09 × 10(-6) cm(2) s(-1)) in the mouse brain.

摘要

张力性神经化学多巴胺活性是许多脑功能的基础；然而，关于这一重要浓度尚未达成共识。在这项工作中，我们引入体内快速扫描控制吸附伏安法来报告小鼠脑中的张力性多巴胺浓度（90±9 nM）和多巴胺扩散系数（1.05±0.09×10(-6) cm(2) s(-1)）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1836/4825181/bc9e2df7c642/nihms768627f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1836/4825181/a8673b89e273/nihms768627f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1836/4825181/38fcf3e17a55/nihms768627f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1836/4825181/bc9e2df7c642/nihms768627f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1836/4825181/a8673b89e273/nihms768627f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1836/4825181/38fcf3e17a55/nihms768627f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1836/4825181/bc9e2df7c642/nihms768627f3.jpg

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