通过气相色谱-质谱联用技术对帕金森病脑组织中多巴胺代谢物的确认。
Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry.
作者信息
Mattammal M B, Chung H D, Strong R, Hsu F F
机构信息
Geriatric Research, Education and Clinical Center, VA Medical Center, St. Louis, MO 63104.
出版信息
J Chromatogr. 1993 May 5;614(2):205-12. doi: 10.1016/0378-4347(93)80310-z.
PMID:8314932
Abstract
Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.
摘要
气相色谱 - 质谱联用技术被用于鉴定从帕金森病脑组织黑质中分离出的一种多巴胺代谢产物。多巴胺与单胺氧化酶B孵育产生了相同的产物，该产物被鉴定为3,4 - 二羟基苯乙醛。通过化学合成、亚稳离子测量和高分辨率质谱确定了该化合物的结构。
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