Wu Yanling, Ding Yanping, Tanaka Yoshimasa, Zhang Wen
1. Lab of Molecular Immunology, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Hangzhou, 310051, China; ; 2. Lab of Chemical Biology and Molecular Drug Design, College of Pharmaceutical Science, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou, 310014, China;
3. Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Int J Med Sci. 2014 Sep 6;11(11):1185-200. doi: 10.7150/ijms.10001. eCollection 2014.
Type 2 diabetes is a serious and common chronic disease resulting from a complex inheritance-environment interaction along with other risk factors such as obesity and sedentary lifestyle. Type 2 diabetes and its complications constitute a major worldwide public health problem, affecting almost all populations in both developed and developing countries with high rates of diabetes-related morbidity and mortality. The prevalence of type 2 diabetes has been increasing exponentially, and a high prevalence rate has been observed in developing countries and in populations undergoing "westernization" or modernization. Multiple risk factors of diabetes, delayed diagnosis until micro- and macro-vascular complications arise, life-threatening complications, failure of the current therapies, and financial costs for the treatment of this disease, make it necessary to develop new efficient therapy strategies and appropriate prevention measures for the control of type 2 diabetes. Herein, we summarize our current understanding about the epidemiology of type 2 diabetes, the roles of genes, lifestyle and other factors contributing to rapid increase in the incidence of type 2 diabetes. The core aims are to bring forward the new therapy strategies and cost-effective intervention trials of type 2 diabetes.
2型糖尿病是一种严重且常见的慢性疾病，由复杂的遗传-环境相互作用以及肥胖和久坐不动的生活方式等其他风险因素导致。2型糖尿病及其并发症构成了一个重大的全球公共卫生问题，在发达国家和发展中国家几乎影响所有人群，糖尿病相关的发病率和死亡率很高。2型糖尿病的患病率一直在呈指数级增长，在发展中国家以及正在经历“西方化”或现代化的人群中观察到高患病率。糖尿病的多种风险因素、在微血管和大血管并发症出现之前延迟诊断、危及生命的并发症、当前治疗方法的失败以及治疗该疾病的财务成本，使得有必要制定新的有效治疗策略和适当的预防措施来控制2型糖尿病。在此，我们总结了我们目前对2型糖尿病流行病学、基因、生活方式和其他导致2型糖尿病发病率迅速上升的因素的作用的理解。核心目标是提出2型糖尿病的新治疗策略和具有成本效益的干预试验。
