Firoozi Manijeh, Besharat Mohammad Ali
Dept. of Psychology, University of Tehran, Tehran, Iran.
Iran J Cancer Prev. 2013 Winter;6(1):1-7.
Malignancy and its treatments could cause disturbance in homeostasisof body such as cortisol secretion. The present study has investigated the effects of cortisol level imbalance in behavioral and emotional adjustments.
Seventy-eight children with Acute Lymphoblastic Leukemia (ALL) have involved in this study. Their salivary cortisol level, which were sensitive to pain and disruptive behaviors, have measured.
CORTISOL LEVEL EFFECT IN DIFFERENT PERIODS: within duration of reaction to pain, sensitivity to pain and disruptive behaviors have evaluated. In addition abnormal regulation of cortisol levels have shown a very strong relationship between sensitivity to pain and the disruptive behaviors. Cortisol suppression was responsible for adjustment by the participants to stressful conditions.
Previous investigations have shown that there is a low reaction to stressor which decreases the vitality as well as impairing a negative memory in low cortisol levels. The findings of the present study demonstrated a nonlinear relation between cortisol level and sensitivity to pain as well as disruptive behaviors. Therefore, regulation of cortisol- up and down- is predisposed to maladjustment.
恶性肿瘤及其治疗可能会导致身体内环境稳态的紊乱，如皮质醇分泌异常。本研究旨在探讨皮质醇水平失衡对行为和情绪调节的影响。
78名急性淋巴细胞白血病（ALL）患儿参与了本研究。测量了他们对疼痛和破坏性行为敏感的唾液皮质醇水平。
不同时期皮质醇水平的影响：在对疼痛的反应期间，评估了对疼痛的敏感性和破坏性行为。此外，皮质醇水平的异常调节表明对疼痛的敏感性与破坏性行为之间存在非常强的关联。皮质醇抑制作用促使参与者适应压力环境。
先前的研究表明，在低皮质醇水平下，对应激源的反应较低，这会降低活力并损害负面记忆。本研究结果表明皮质醇水平与对疼痛的敏感性以及破坏性行为之间存在非线性关系。因此，皮质醇水平的上调和下调调节都易导致适应不良。
