胃同时发生腺癌和胃肠道间质瘤：一例报告

Khoshnevis Jalaluddin, Rakhshan Azadeh, Sobhiyeh Mohammad Reza, Gholizadeh Barmak, Rahbari Ali, Adhami Farideh, Lotfollahzadeh Saran

Dept. of General and Vascular Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran ; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Iran J Cancer Prev. 2013 Winter;6(1):55-8.

Simultaneous a collision tumor of stomach consisting of adenocarcinoma and Gastrointestinal Stromal Tumor (GIST) is very rare based on our knowledge. This coexistence has rarely been reported in literatures. We report a case of 64-year-old woman who has diagnosed with prepyloric poorly-differentiated diffuse signet-ring cell type adenocarcinoma and has undergone an elective D2 total gastrectomy. During operation another mass in fundic body region has found. The pathologic examination of the mass has shown GIST. Immunohistochemical staining for CD117 and Desmin was positive whilst that for S100 was negative. This case reports the simultaneous two tumors development of different histotypes and natures in the same organ.

据我们所知，胃同时发生由腺癌和胃肠道间质瘤（GIST）组成的碰撞瘤非常罕见。这种共存情况在文献中鲜有报道。我们报告一例64岁女性，她被诊断为幽门前低分化弥漫印戒细胞型腺癌，并接受了择期D2全胃切除术。手术过程中，在胃体部发现了另一个肿块。该肿块的病理检查显示为GIST。CD117和结蛋白的免疫组化染色呈阳性，而S100的染色呈阴性。本病例报告了同一器官中同时发生的两种不同组织学类型和性质的肿瘤。