Wilms瘤中Her2/neu的表达及其与组织病理学结果的相关性
Her2/neu Expression in Wilms' Tumor and Correlation With Histopathologic Findings.
作者信息
Babashahi Mashaallah, Mehrazma Mitra, Nasiri Seyed Javad, Azizi Jalilian Farid, Rezaei-Tavirani Mostafa
机构信息
Dept. of Pathology, Iran University of Medical Sciences, Tehran, Iran.
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Iran J Cancer Prev. 2013 Summer;6(3):160-4.
BACKGROUND
Wilms' tumor is an emberyonal tumor arising from remnants of immature renal tissue. Her2/neu is an onco-protein which mediates cellular proliferation, differentiation and survival.
METHODS
In the current study, we analyzed Her2/neu expression in 40 Wilms' tumors. The clinico-demographic data of 40 patients with Wilms' tumor were retrieved. Immunohistochemical staining for HER2/neu was performed. Her2/neuimmunoreactivity was evaluated by Canadian Consensus 2007 scoring system.
RESULTS
Among the 38 specimens with epithelial component, 68.5% were positive for Her2/neu, whereas there was immunoreactivity in 37% of 38 blastemal, and 12% of 31 stromal components. The Her2/neu expression was significantly higher in early stages (81.5%) than in advanced stages (36.4%) in epithelial component, but not in other components.
CONCLUSION
This study suggested that Her2/neuexpression is associated with epithelial cell differentiation accompanied by lower stages of tumor. No significant relationship was found between Her2/neu positivity and tumor size and patient's age and gender.
背景
肾母细胞瘤是一种起源于未成熟肾组织残余的胚胎性肿瘤。Her2/neu是一种介导细胞增殖、分化和存活的癌蛋白。
方法
在本研究中，我们分析了40例肾母细胞瘤中Her2/neu的表达情况。收集了40例肾母细胞瘤患者的临床人口统计学数据。进行了HER2/neu的免疫组织化学染色。采用2007年加拿大共识评分系统评估Her2/neu免疫反应性。
结果
在38个具有上皮成分的标本中，68.5%的Her2/neu呈阳性，而在38个胚芽成分中有37%呈免疫反应性，在31个间质成分中有12%呈免疫反应性。上皮成分中Her2/neu的表达在早期（81.5%）显著高于晚期（36.4%），但在其他成分中并非如此。
结论
本研究表明，Her2/neu的表达与上皮细胞分化有关，且与肿瘤分期较低有关。未发现Her2/neu阳性与肿瘤大小、患者年龄和性别之间存在显著关系。
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