Huang Chien-Hao, Jeng Wen-Juei, Ho Yu-Pin, Teng Wei, Chen Wei-Ting, Chen Yi-Cheng, Lin Shi-Ming, Chiu Cheng-Tang, Sheen I-Shyan, Lin Chun-Yen
Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang-Gung University, Taoyuan, Taiwan.
J Gastroenterol Hepatol. 2015 Apr;30(4):775-83. doi: 10.1111/jgh.12781.
Patients with liver cirrhosis (LC) were regarded as immunocompromised status with high incidence of bacterial infection. Regulatory T cell (Treg cell) is known as an immune suppressor and also plays an important role in patients with sepsis. This paper aims to study the role of Treg cells in patients with liver cirrhosis and their correlations to bacterial complications.
Thirty-three normal controls (NC) and 82 cirrhotic patients were enrolled for the case-control study. The Treg cells, defined as CD4+ CD25+ Foxp3+ T cells, in peripheral blood of these patients were evaluated.
The percentage of Treg cells increased significantly in patients with liver cirrhosis when compared with normal volunteers. Furthermore, this increase of Treg cells was mainly memory phenotype defined as CD45RO+ Treg cells and was significantly correlated with serum bilirubin levels as evaluated by multiple linear regression analysis. In addition, the tumor necrosis factor (TNF)-α receptor II (TNFRII) expression also significantly increased on Treg cells in these patients. Interestingly, these membranous TNFRII would be shed and released into supernatant. Lastly, this increased percentage of Treg cells in cirrhotic patients correlate well with and predict subsequent bacterial complications.
The Treg cells, mainly with memory phenotype and with high TNFRII expression, increased significantly in patients with liver cirrhosis and significantly correlated with the serum bilirubin levels. Furthermore, this increased Treg cells correlate with and predict subsequent bacterial complications in cirrhotic patients.
肝硬化（LC）患者被视为免疫功能低下状态，细菌感染发生率高。调节性T细胞（Treg细胞）是一种免疫抑制细胞，在脓毒症患者中也起重要作用。本文旨在研究Treg细胞在肝硬化患者中的作用及其与细菌并发症的相关性。
纳入33名正常对照者（NC）和82名肝硬化患者进行病例对照研究。评估这些患者外周血中定义为CD4 + CD25 + Foxp3 +的Treg细胞。
与正常志愿者相比，肝硬化患者的Treg细胞百分比显著增加。此外，Treg细胞的这种增加主要是记忆表型，定义为CD45RO + Treg细胞，经多元线性回归分析评估，其与血清胆红素水平显著相关。此外，这些患者Treg细胞上的肿瘤坏死因子（TNF）-α受体II（TNFRII）表达也显著增加。有趣的是，这些膜性TNFRII会脱落并释放到上清液中。最后，肝硬化患者中Treg细胞百分比的增加与随后的细菌并发症密切相关并可预测。
主要具有记忆表型且TNFRII表达高的Treg细胞在肝硬化患者中显著增加，且与血清胆红素水平显著相关。此外，Treg细胞的增加与肝硬化患者随后的细菌并发症相关并可预测。
