Cea Soriano Lucía, Wallander Mari-Ann, Andersson Susan, Filonenko Anna, García Rodríguez Luis Alberto
Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid, Spain.
Pharmacoepidemiol Drug Saf. 2015 Jan;24(1):52-8. doi: 10.1002/pds.3710. Epub 2014 Sep 24.
The purpose of this study was to determine the continuation rates of new users of long-acting reversible contraceptive (LARC) methods in the UK, using data from general practice.
We conducted an observational study using a general practitioner (GP) database, The Health Improvement Network (THIN). The methods studied were copper intrauterine devices (Cu-IUDs), levonorgestrel-releasing intrauterine system (LNG-IUS), progestogen-only implants and progestogen-only injections. The study population comprised women in THIN aged 18-44 years during the period 2004-2009 who had been registered with their GP for at least 5 years, with a computerized prescription history of at least 1 year. Using computer algorithms, the database was searched for the Read and Multilex codes for each LARC method. New LARC users were identified and followed until there was a record indicating termination of use or the study period ended.
The proportion of women who discontinued use during the same year of administration was 7.5% for Cu-IUDs, 10.6% for LNG-IUS, 13.2% for progestogen-only implants and 54.4% for progestogen-only injections. By the end of the study, a higher proportion of Cu-IUD and LNG-IUS users (21.1 and 18.6%, respectively) undertook consecutive use of the same method than progestogen-only implant users (10.7%). Manual review of computerized profiles demonstrated the validity of this approach.
In the UK, the continuation rates of LARCs are high, and approximately one fifth of women chose to have a second intrauterine device fitted after expiry of the first device. A validation step demonstrated the reliability of the methodology and computer algorithms used.
本研究旨在利用全科医疗数据,确定英国长效可逆避孕(LARC)方法新使用者的续用率。
我们使用全科医生(GP)数据库“健康改善网络”(THIN)进行了一项观察性研究。所研究的方法包括铜宫内节育器(Cu-IUD)、左炔诺孕酮宫内缓释系统(LNG-IUS)、仅含孕激素的植入剂和仅含孕激素的注射剂。研究人群包括2004年至2009年期间年龄在18 - 44岁、在其全科医生处注册至少5年且有至少1年计算机化处方记录的THIN数据库中的女性。利用计算机算法,在数据库中搜索每种LARC方法的Read和Multilex编码。识别出新的LARC使用者并进行随访,直至有记录表明停止使用或研究期结束。
在使用的同一年停止使用的女性比例,Cu-IUD为7.5%,LNG-IUS为10.6%,仅含孕激素的植入剂为13.2%,仅含孕激素的注射剂为54.4%。到研究结束时,连续使用同一种方法的Cu-IUD和LNG-IUS使用者比例更高(分别为21.1%和18.6%),高于仅含孕激素的植入剂使用者(10.7%)。对计算机化档案的人工审查证明了这种方法的有效性。
在英国,LARC的续用率很高,约五分之一的女性在第一个宫内节育器到期后选择放置第二个。验证步骤证明了所使用方法和计算机算法的可靠性。