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利用健康改善网络的数据得出的英国全科医疗中长效可逆避孕法的续用率。

The continuation rates of long-acting reversible contraceptives in UK general practice using data from The Health Improvement Network.

作者信息

Cea Soriano Lucía, Wallander Mari-Ann, Andersson Susan, Filonenko Anna, García Rodríguez Luis Alberto

机构信息

Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid, Spain.

出版信息

Pharmacoepidemiol Drug Saf. 2015 Jan;24(1):52-8. doi: 10.1002/pds.3710. Epub 2014 Sep 24.

Abstract

PURPOSE

The purpose of this study was to determine the continuation rates of new users of long-acting reversible contraceptive (LARC) methods in the UK, using data from general practice.

METHODS

We conducted an observational study using a general practitioner (GP) database, The Health Improvement Network (THIN). The methods studied were copper intrauterine devices (Cu-IUDs), levonorgestrel-releasing intrauterine system (LNG-IUS), progestogen-only implants and progestogen-only injections. The study population comprised women in THIN aged 18-44 years during the period 2004-2009 who had been registered with their GP for at least 5 years, with a computerized prescription history of at least 1 year. Using computer algorithms, the database was searched for the Read and Multilex codes for each LARC method. New LARC users were identified and followed until there was a record indicating termination of use or the study period ended.

RESULTS

The proportion of women who discontinued use during the same year of administration was 7.5% for Cu-IUDs, 10.6% for LNG-IUS, 13.2% for progestogen-only implants and 54.4% for progestogen-only injections. By the end of the study, a higher proportion of Cu-IUD and LNG-IUS users (21.1 and 18.6%, respectively) undertook consecutive use of the same method than progestogen-only implant users (10.7%). Manual review of computerized profiles demonstrated the validity of this approach.

CONCLUSIONS

In the UK, the continuation rates of LARCs are high, and approximately one fifth of women chose to have a second intrauterine device fitted after expiry of the first device. A validation step demonstrated the reliability of the methodology and computer algorithms used.

摘要

目的

本研究旨在利用全科医疗数据,确定英国长效可逆避孕(LARC)方法新使用者的续用率。

方法

我们使用全科医生(GP)数据库“健康改善网络”(THIN)进行了一项观察性研究。所研究的方法包括铜宫内节育器(Cu-IUD)、左炔诺孕酮宫内缓释系统(LNG-IUS)、仅含孕激素的植入剂和仅含孕激素的注射剂。研究人群包括2004年至2009年期间年龄在18 - 44岁、在其全科医生处注册至少5年且有至少1年计算机化处方记录的THIN数据库中的女性。利用计算机算法,在数据库中搜索每种LARC方法的Read和Multilex编码。识别出新的LARC使用者并进行随访,直至有记录表明停止使用或研究期结束。

结果

在使用的同一年停止使用的女性比例,Cu-IUD为7.5%,LNG-IUS为10.6%,仅含孕激素的植入剂为13.2%,仅含孕激素的注射剂为54.4%。到研究结束时,连续使用同一种方法的Cu-IUD和LNG-IUS使用者比例更高(分别为21.1%和18.6%),高于仅含孕激素的植入剂使用者(10.7%)。对计算机化档案的人工审查证明了这种方法的有效性。

结论

在英国,LARC的续用率很高,约五分之一的女性在第一个宫内节育器到期后选择放置第二个。验证步骤证明了所使用方法和计算机算法的可靠性。

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