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全民免费覆盖对长效可逆避孕法及所有处方避孕法使用情况的影响:基于人群的对照中断时间序列分析

Effect of universal no-cost coverage on use of long-acting reversible contraception and all prescription contraception: population based, controlled, interrupted time series analysis.

作者信息

Schummers Laura, Cheng Lucy, Odendaal Martin, Rodriguez-Llorian Elisabet, Kuo I Fan, Norman Wendy V, Black Amanda, Stucchi Andrea, Helmer-Smith Mary, Nethery Elizabeth, Downey Amanda, Guindon G Emmanuel, McGrail Kim, Brennand Erin A, Lee Sabrina, Metcalfe Amy, Bryan Stirling, Darling Elizabeth K, Bertazzon Stefania, Poliquin Vanessa, Nickel Nathan C, Clement Fiona, Law Michael R

机构信息

Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada

Collaboration for Outcomes Research and Evaluation, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.

出版信息

BMJ. 2025 Jul 28;390:e083874. doi: 10.1136/bmj-2024-083874.

DOI:10.1136/bmj-2024-083874
PMID:40721270
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12301903/
Abstract

OBJECTIVE

To estimate effects of a policy introducing universal, no-cost public coverage for prescription contraception on use in British Columbia, Canada.

DESIGN

Population based, controlled, interrupted time series analysis.

SETTING

10 Canadian provinces.

PARTICIPANTS

Prescription medications dispensed to reproductive aged (15-49 years) female residents of British Columbia, Canada, compared with a synthetic control derived from the nine other Canadian provinces and a population based cohort of 859 845 female individuals in British Columbia (age 15-49 years) between 1 April 2021 and 30 June 2024.

INTERVENTION

Introduction of a universal contraception coverage policy in April 2023, where the public insurer pays 100% of prescription costs.

OUTCOME MEASURES

Number of monthly dispensations for long-acting reversible contraception (LARC) and number of monthly dispensations for all forms of prescription contraception (including LARC), percentage of reproductive aged female residents using LARC and using all forms of prescription contraception, and the proportion of people using prescription contraception who use LARC (LARC market share). Segmented regression models were used to estimate policy effects by comparing the expected outcome values after 15 months of the policy (ie, the counterfactual, derived from trends before the policy and changes in the control) with the observed values, with 95% confidence intervals (CIs) estimated using bootstrapping.

RESULTS

In April 2021, 3249 (95% CI 3066 to 3391) LARC prescriptions were dispensed in British Columbia, with a declining slope trend of -17 (-30 to -7) fewer dispensed per month before the policy. Monthly LARC dispensations increased by 1050 (942 to 1487) immediately after British Columbia's policy change and saw a steady increasing trend after the policy introduction. An additional 1273 (963 to 1698) monthly LARC prescriptions were dispensed 15 months after policy implementation compared with the expected volume, representing an estimated 1.49-fold (1.34 to 1.77) increase. Dispensations for all prescription contraception (including LARC) increased by 1981 (356 to 3324) per month, representing a 1.04-fold (1.01 to 1.07) increase. Among the 859 845 female residents aged 15-49 years in the population, 9.1% were using LARC in April 2021. 15 months after the policy, 11 375 (10 273 to 13 013) more individuals were using LARC than expected without the policy, representing an additional 1.3% (1.2% to 1.5%) of the population. The policy led to an additional 1.7% (1.5% to 2.3%) of the population using any prescription contraception. 15 months after the policy, the LARC market share was 1.9% (1.2% to 2.3%) higher than expected.

CONCLUSIONS

Universal, no-cost public coverage in British Columbia increased prescription contraception use overall, driven by increased LARC use. As such, cost seems to be an important contributor to contraception use and method selection at the population level.

摘要

目的

评估一项在加拿大不列颠哥伦比亚省推行的为处方避孕药提供全民免费公共保险政策的效果。

设计

基于人群的对照中断时间序列分析。

背景

加拿大10个省份。

参与者

加拿大不列颠哥伦比亚省15至49岁育龄女性居民所配的处方药,与来自加拿大其他9个省份的合成对照以及2021年4月1日至2024年6月30日期间不列颠哥伦比亚省859845名15至49岁女性个体的人群队列进行比较。

干预措施

2023年4月引入全民避孕保险政策,公共保险公司支付100%的处方费用。

观察指标

长效可逆避孕法(LARC)的月配药数量、所有形式处方避孕药(包括LARC)的月配药数量、使用LARC和所有形式处方避孕药的育龄女性居民百分比,以及使用处方避孕药的人群中使用LARC的比例(LARC市场份额)。采用分段回归模型,通过将政策实施15个月后的预期结果值(即反事实,源自政策实施前的趋势和对照的变化)与观察值进行比较来估计政策效果,使用自抽样法估计95%置信区间(CIs)。

结果

2021年4月,不列颠哥伦比亚省发放了3249份(95%CI 3066至3391)LARC处方,政策实施前每月发放量呈下降趋势,斜率为每月减少17份(-30至-7)。不列颠哥伦比亚省政策改变后,LARC月配药量立即增加了1050份(942至1487),政策实施后呈稳定增长趋势。与预期数量相比,政策实施15个月后,每月额外发放了1273份(963至1698)LARC处方,估计增长了1.49倍(1.34至1.77)。所有处方避孕药(包括LARC)的配药量每月增加了1981份(356至3324),增长了1.04倍(1.01至1.07)。在该人群中859845名15至49岁的女性居民中,2021年4月有9.1%的人使用LARC。政策实施15个月后,使用LARC的人数比没有该政策时预期的多11375人(10273至13013人),占总人口的1.3%(1.2%至1.5%)。该政策使使用任何处方避孕药的人口增加了1.7%(1.5%至2.3%)。政策实施15个月后,LARC市场份额比预期高1.9%(1.2%至2.3%)。

结论

不列颠哥伦比亚省的全民免费公共保险总体上增加了处方避孕药的使用,这是由LARC使用增加推动的。因此,成本似乎是人群层面避孕药使用和方法选择的一个重要因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548b/12301903/6f545f41222b/schl083874.f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548b/12301903/fac3df932c0a/schl083874.f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548b/12301903/1ca6df884626/schl083874.f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548b/12301903/58e53e153f10/schl083874.f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548b/12301903/6f545f41222b/schl083874.f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548b/12301903/fac3df932c0a/schl083874.f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548b/12301903/1ca6df884626/schl083874.f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548b/12301903/58e53e153f10/schl083874.f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/548b/12301903/6f545f41222b/schl083874.f4.jpg

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