Agostini A, Godard C, Laurendeau C, Benmahmoud Zoubir A, Lafuma A, Lévy-Bachelot L, Gourmelen J, Linet T
a Gynecology-Obstetric Department , La Conception Hospital , Marseille , France.
b MSD France , Courbevoie , France.
Eur J Contracept Reprod Health Care. 2018 Dec;23(6):421-426. doi: 10.1080/13625187.2018.1535653. Epub 2018 Nov 30.
The aim of this study was to evaluate the continuation rates of reimbursed contraceptive methods in French real-world conditions.
A retrospective cohort study using a representative sample of the national health insurance database, the General Sample of Beneficiaries (Echantillon Généralistes des Bénéficiaires [EGB]), was performed between 2006 and 2012. Selected women were ≥15 years of age and had started a reimbursed contraceptive method between 2009 and 2012 without prior reimbursement for an implant or an intrauterine contraceptive method between 2006 and 2008. The outcome of interest was the continuation rates, defined as the probability of women initiating a contraceptive method and continuing to use the same method over time. Continuation rates were assessed for up to 2 years. Only the first contraceptive method used during the study period was considered in the analysis. Non-parametric Kaplan-Meier survival analysis was used to assess continuation rates.
A population of 42,365 women representative of the 4,109,405 French women initiating any reimbursed method between 2009 and 2012 was identified in the EGB: 74.5% of women used oral contraceptives, 12.8% the levonorgestrel-releasing intrauterine system (LNG-IUS), 9.2% the copper intrauterine device (Cu-IUD) and 3.5% the subdermal etonogestrel (ENG) implant. The 2 year continuation rates varied from 9.1% for progestin-only oral contraceptives, 27.6% for first to second generation combined oral contraceptives (COCs) and 33.4% for third generation COCs to 83.6% for the ENG implant, 88.1% for the Cu-IUD and 91.1% for the LNG-IUS.
This study conducted in real-world conditions showed that long-acting reversible contraceptive (LARC) methods remain rarely used in France despite high continuation rates over 2 years. Increasing the use of LARC methods is therefore a public health priority.
本研究旨在评估法国实际情况下报销的避孕方法的持续使用率。
2006年至2012年间,利用全国医疗保险数据库的代表性样本——受益人总样本(Echantillon Généralistes des Bénéficiaires [EGB])进行了一项回顾性队列研究。入选女性年龄≥15岁,在2009年至2012年间开始使用报销的避孕方法,且在2006年至2008年间未曾报销过植入剂或宫内避孕方法。感兴趣的结果是持续使用率,定义为女性开始使用一种避孕方法并随时间继续使用同一方法的概率。持续使用率评估长达2年。分析中仅考虑研究期间使用的第一种避孕方法。采用非参数Kaplan-Meier生存分析评估持续使用率。
在EGB中确定了42365名女性,她们代表了2009年至2012年间开始使用任何报销方法的4109405名法国女性:74.5%的女性使用口服避孕药,12.8%使用左炔诺孕酮宫内缓释系统(LNG-IUS),9.2%使用铜宫内节育器(Cu-IUD),3.5%使用皮下依托孕烯(ENG)植入剂。2年持续使用率从仅含孕激素的口服避孕药的9.1%、第一代和第二代复方口服避孕药(COC)的27.6%、第三代COC的33.4%到ENG植入剂的83.6%、Cu-IUD的88.1%和LNG-IUS的91.1%不等。
在实际情况下进行的这项研究表明,长效可逆避孕(LARC)方法在法国仍很少使用,尽管2年持续使用率很高。因此,增加LARC方法的使用是一项公共卫生优先事项。