Komlos L, Sirota L, Notman J, Dulitzky F, Hart J, Goldman J, Halbrecht I
B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Petah Tiqwa, Israel.
Gynecol Obstet Invest. 1989;27(2):62-9. doi: 10.1159/000293620.
One-way-stimulated mixed mother-newborn lymphocyte cultures (MMNLC) from male and female newborns were evaluated and compared shortly after delivery. Newborn sex-correlated differences were observed in the strength of the MMNLC reactivity with responding maternal as well as newborn cells. The reactivity of MMNLC with responding maternal cells from male as compared to female newborns was significantly less inhibited in maternal and newborn serum. The inhibitory effect of maternal serum on maternal and male newborn lymphocytes in MMNLC seems to be correlated to the sex of the previous child delivered and was significantly lower when the present as well as the previous baby were of the same sex, e.g. 2 boys. The results suggest that fetal-male-specific Y-chromosome-correlated histocompatibility antigens may specifically influence the maternal immune response to her fetus.
在分娩后不久，对来自男性和女性新生儿的单向刺激混合母婴淋巴细胞培养物（MMNLC）进行了评估和比较。在MMNLC与反应性母体细胞以及新生儿细胞的反应强度方面，观察到了与新生儿性别相关的差异。与女性新生儿相比，男性新生儿的MMNLC与反应性母体细胞的反应性在母体和新生儿血清中受到的抑制明显较少。母体血清对MMNLC中母体和男性新生儿淋巴细胞的抑制作用似乎与前一个分娩孩子的性别相关，当本次和前一个婴儿性别相同时，例如两个男孩，这种抑制作用明显较低。结果表明，胎儿男性特异性Y染色体相关组织相容性抗原可能会特异性地影响母体对其胎儿的免疫反应。
