Torres-Ibarra Leticia, Conde-Glez Carlos J, Salmerón Jorge, Palefsky Joel, Hernández-Nevares Pilar, Sánchez-Alemán Miguel Angel, Magis-Rodríguez Carlos, Lazcano-Ponce Eduardo
Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, 62508 Cuernavaca, Mexico.
Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, 62508 Cuernavaca, Mexico; Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, 62450 Cuernavaca, Mexico.
Prev Med. 2014 Dec;69:157-64. doi: 10.1016/j.ypmed.2014.09.011. Epub 2014 Sep 22.
To describe the prevalence of specific HPV types among HIV-positive men who have sex with men (MSM), particularly the presence of HPV-16 and/or -18, and to determine the factors associated with anal HPV-16/18 infections.
This is a cross-sectional study from a baseline cohort of 525 HIV-positive MSM, who attended an HIV Clinic in Mexico City. Socio-demographic characteristics, sexual behaviors and HIV-related parameters were assessed. Anal samples were tested for HPV DNA using the Linear Array HPV genotyping assay.
The overall prevalence of any HPV type in the anal canal among 446 participants was 93.1%. At least one oncogenic HPV type was detected in 72.2% of the subjects and HPV-16 and/or18 were detected in 30.7%. Additionally, 76.9% of patients were infected with multiple HPV types. Having more than 10 receptive sexual partners in the last 6months (OR=2.30; 95% CI 1.12-4.74) and a CD4 cell count ≤350cells/μL (OR=1.97; 95% CI 1.26-3.09) were factors positively associated with HPV-16/18 infection in the anal canal.
Co-infection with HPV-16/18 and other oncogenic types are predominant in this group of HIV-positive MSM. The recognition of infection with specific oncogenic types will be of aid in designing future preventive strategies that target this high-risk population.
描述男男性行为者（MSM）中HIV阳性者特定HPV类型的流行情况，尤其是HPV - 16和/或 - 18的存在情况，并确定与肛门HPV - 16/18感染相关的因素。
这是一项横断面研究，来自墨西哥城一家HIV诊所的525名HIV阳性MSM的基线队列。评估了社会人口学特征、性行为和与HIV相关的参数。使用线性阵列HPV基因分型检测法对肛门样本进行HPV DNA检测。
446名参与者中肛管中任何HPV类型的总体流行率为93.1%。72.2%的受试者检测到至少一种致癌性HPV类型，30.7%检测到HPV - 16和/或18。此外，76.9%的患者感染了多种HPV类型。在过去6个月内有超过10个性伴侣（OR = 2.30；95%CI 1.12 - 4.74）和CD4细胞计数≤350个细胞/μL（OR = 1.97；95%CI 1.26 - 3.09）是与肛管HPV - 16/18感染呈正相关的因素。
在这组HIV阳性MSM中，HPV - 16/18与其他致癌类型的合并感染很常见。识别特定致癌类型的感染将有助于设计针对这一高危人群的未来预防策略。
