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Urol Clin North Am. 2016 Nov;43(4):419-425. doi: 10.1016/j.ucl.2016.06.003. Epub 2016 Sep 3.
2
Tumor Staging and HPV-Related Oropharyngeal Cancer.肿瘤分期与HPV相关的口咽癌
Recent Results Cancer Res. 2017;206:123-133. doi: 10.1007/978-3-319-43580-0_9.
3
HPV in Head and Neck Cancer-30 Years of History.头颈部癌症中的人乳头瘤病毒——30年历程
Recent Results Cancer Res. 2017;206:3-25. doi: 10.1007/978-3-319-43580-0_1.
4
Papillomavirus and cancers: should we extend vaccination to boys in France?人乳头瘤病毒与癌症：法国是否应将疫苗接种范围扩大至男孩？
J Public Health (Oxf). 2017 Dec 1;39(4):e229-e234. doi: 10.1093/pubmed/fdw099.
5
Human papillomavirus and gastrointestinal cancer: A review.人乳头瘤病毒与胃肠道癌：综述
World J Gastroenterol. 2016 Sep 7;22(33):7415-30. doi: 10.3748/wjg.v22.i33.7415.
6
[CONDYDAV: A multicentre observational study of patients presenting external genital warts in France].[康迪达夫：法国一项关于患有外生殖器疣患者的多中心观察性研究]
Ann Dermatol Venereol. 2016 Nov;143(11):675-681. doi: 10.1016/j.annder.2016.05.013. Epub 2016 Sep 19.
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National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged 13-17 Years - United States, 2015.国家、地区、州和选定的局部地区 13-17 岁青少年疫苗接种覆盖率 - 美国，2015 年。
MMWR Morb Mortal Wkly Rep. 2016 Aug 26;65(33):850-8. doi: 10.15585/mmwr.mm6533a4.
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HPV vaccination impact on a cervical cancer screening program: methods of the FASTER-Tlalpan Study in Mexico.人乳头瘤病毒疫苗接种对宫颈癌筛查项目的影响：墨西哥FASTER - 特拉尔潘研究方法
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Cancer patterns, trends and projections in Latin America and the Caribbean: a global context.拉丁美洲和加勒比地区的癌症模式、趋势及预测：全球背景下的情况
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The prevalence of human papillomavirus infections and associated risk factors in men-who-have-sex-with-men in Cape Town, South Africa.南非开普敦男男性行为者中人乳头瘤病毒感染的患病率及相关风险因素
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墨西哥男性肛门人乳头瘤病毒感染的患病率和发病率：制定普遍预防政策的必要性。

Prevalence and incidence of anal human papillomavirus infection in Mexican men: Need for universal prevention policies.

作者信息

Posso Hector, León-Maldonado Leith, Allen-Leigh Betania, Salmerón Jorge, Quiterio Manuel, Giuliano Anna R, Sudenga Staci L, Nyitray Alan G, Torres B Nelson, Abrahamsen Martha, Lazcano-Ponce Eduardo

机构信息

Universidad de la Sabana. Chia-Cundinamarca, Colombia.

Cátedra Conacyt, Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, México.

出版信息

Salud Publica Mex. 2018 Nov-Dec;60(6):645-652. doi: 10.21149/8454.

DOI:10.21149/8454
PMID:30699269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6642746/
Abstract

OBJECTIVE

Describe the natural history of anal HPV among men.

MATERIALS AND METHODS

Prospective study among men 18-70 years (n=665), from Cuernavaca, Mexico who completed questionnaires and provided specimens (HPV genotyped) at enrollment and 1+ follow-up visit. HPV prevalence and incidence were estimated. Prevalence ratios were calculated with Poisson regression using robust variance estimation. Person-time for incident HPV infection was estimated using number of events modeled as Poisson variable for total person-months.

RESULTS

Anal infection prevalence: any HPV type=15%, high-risk=8.4%, HPV16=1.4%, tetravalent vaccine types (4vHPV)=4.4%, nonavalent vaccine types (9vHPV)=6.3%. Factors associated with prevalence: 50+ lifetime female sex partners (adjusted prevalence ratio, a PR=3.25, 95% CI:1.12- 9.47), 10+ lifetime male sex partners (aPR=3.06, 95%CI:1.4- 6.68), and 1+ recent male anal sex partners (aPR=2.28, 95%CI:1.15-4.5). Anal incidence rate: high-risk HPV=7.8/1000 person-months (95%CI:6.0-10.1), HPV16=1.8/1000 personmonths (95%CI:1.1-2.9),4vHPV=3.4/1000 person-months (95%CI:2.3-4.9) and 9vHPV=5.5/1000 person-months (95%CI:4.1-7.5).

CONCLUSIONS

Implementation of universal HPV vaccination programs, including men, is a public health priority.

摘要

目的

描述男性肛门人乳头瘤病毒（HPV）的自然史。

材料与方法

对来自墨西哥库埃纳瓦卡的18至70岁男性（n = 665）进行前瞻性研究，这些男性在入组时及1次或更多次随访时完成问卷调查并提供标本（进行HPV基因分型）。估计HPV患病率和发病率。使用稳健方差估计的泊松回归计算患病率比值。将事件数建模为总人月数的泊松变量来估计新发HPV感染的人时。

结果

肛门感染患病率：任何HPV类型为15%，高危型为8.4%，HPV16为1.4%，四价疫苗型（4vHPV）为4.4%，九价疫苗型（9vHPV）为6.3%。与患病率相关的因素：终生有50个以上女性性伴侣（调整患病率比值，aPR = 3.25，95%可信区间：1.12 - 9.47），终生有10个以上男性性伴侣（aPR = 3.06，95%可信区间：1.4 - 6.68），以及近期有1个或更多男性肛门性伴侣（aPR = 2.28，95%可信区间：1.15 - 4.5）。肛门发病率：高危型HPV为7.8/1000人月（95%可信区间：6.0 - 10.1），HPV16为1.8/1000人月（95%可信区间：1.1 - 2.9），4vHPV为3.4/1000人月（95%可信区间：2.3 - 4.9），9vHPV为5.5/1000人月（95%可信区间：4.1 - 7.5）。

结论

实施包括男性在内的普遍HPV疫苗接种计划是公共卫生的优先事项。