College of Chemistry, Fuzhou University, Fuzhou, 350116 (P.R. China); State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Fuzhou, 350002 (P.R. China).
Angew Chem Int Ed Engl. 2014 Nov 17;53(47):12860-4. doi: 10.1002/anie.201407026. Epub 2014 Sep 22.
Circular dichroism is known to be the feature of a chiral agent which has inspired scientist to study the interesting phenomena of circularly polarized light (CPL) modulated molecular chirality. Although several organic molecules or assemblies have been found to be CPL-responsive, the influence of CPL on the assembly of chiral coordination compounds remains unknown. Herein, a chiral coordination polymer, which is constructed from achiral agents, was used to study the CPL-induced enantioselective synthesis. By irradiation with either left-handed or right-handed CPL during the reaction and crystallization, enantiomeric excesses of the crystalline product were obtained. Left-handed CPL resulted in crystals with a left-handed helical structure, and right-handed CPL led to crystals with a right-handed helical structure. It is exciting that the absolute asymmetric synthesis of a chiral coordination polymer could be enantioselective when using CPL, and provides a strategy for the control of the chirality of chiral coordination polymers.
圆二色性是手性试剂的特征，这启发科学家研究圆偏振光（CPL）调制分子手性的有趣现象。尽管已经发现了几种对 CPL 有响应的有机分子或组装体，但 CPL 对手性配位化合物组装的影响尚不清楚。在此，使用手性配位聚合物，由非手性试剂构建，用于研究 CPL 诱导的对映选择性合成。通过在反应和结晶过程中用左旋或右旋 CPL 照射，获得了结晶产物的对映体过量。左旋 CPL 导致具有左手螺旋结构的晶体，而右旋 CPL 导致具有右手螺旋结构的晶体。令人兴奋的是，当使用 CPL 时，手性配位聚合物的绝对不对称合成可以是对映选择性的，为控制手性配位聚合物的手性提供了一种策略。
