Mueske Nicole M, Ryan Deirdre D, Van Speybroeck Alexander L, Chan Linda S, Wren Tishya A L
Children's Orthopaedic Center, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Dev Med Child Neurol. 2015 Mar;57(3):273-8. doi: 10.1111/dmcn.12591. Epub 2014 Sep 23.
To evaluate fat distribution in children and adolescents with myelomeningocele using dual-energy X-ray absorptiometry (DXA).
Cross-sectional DXA measurements of the percentage of fat in the trunk, arms, legs, and whole body were compared between 82 children with myelomeningocele (45 males, 37 females; mean age 9y 8mo, SD 2y 7mo; 22 sacral, 13 low lumbar, 47 mid lumbar and above) and 119 comparison children (65 males, 54 females; mean age 10y 4mo, SD 2y 4mo). Differences in fat distribution between groups were evaluated using univariate and multivariate analyses.
Children with myelomeningocele had higher total body fat (34% vs 31%, p=0.02) and leg fat (42% vs 35%, p<0.001) than comparison children, but no differences in trunk or arm fat after adjustment for anthropometric measures.
Children with myelomeningocele have higher than normal total body and leg fat, but only children with higher level lesions have increased trunk fat, which may be caused by greater obesity in this group. Quantifying segmental fat distribution may aid in better assessment of excess weight and, potentially, the associated health risks.
使用双能X线吸收测定法（DXA）评估脊髓脊膜膨出患儿及青少年的脂肪分布情况。
比较82例脊髓脊膜膨出患儿（45例男性，37例女性；平均年龄9岁8个月，标准差2岁7个月；22例骶部病变，13例下腰部病变，47例中腰部及以上病变）与119例对照儿童（65例男性，54例女性；平均年龄10岁4个月，标准差2岁4个月）躯干、手臂、腿部及全身脂肪百分比的横断面DXA测量结果。采用单因素和多因素分析评估两组间脂肪分布的差异。
与对照儿童相比，脊髓脊膜膨出患儿的全身脂肪（34%对31%，p=0.02）和腿部脂肪（42%对35%，p<0.001）更高，但在调整人体测量指标后，躯干或手臂脂肪无差异。
脊髓脊膜膨出患儿的全身和腿部脂肪高于正常水平，但只有病变部位较高的患儿躯干脂肪增加，这可能是该组肥胖程度较高所致。量化节段性脂肪分布可能有助于更好地评估超重情况以及潜在的相关健康风险。
