Turney Benjamin, Robertson William, Wiseman Oliver, Amaro Carmen Regina P R, Leitão Victor A, Silva Isabela Leme da, Amaro João Luiz
Department of Urology, University of Oxford, Oxford; United Kingdom.
Deparment of Urolithiasis Research, Cambridge University Hospitals Trust, Cambridge, United Kingdom.
Int Braz J Urol. 2014 Jul-Aug;40(4):507-12. doi: 10.1590/S1677-5538.IBJU.2014.04.09.
The aim was to confirm that PSF (probability of stone formation) changed appropriately following medical therapy on recurrent stone formers.
Data were collected on 26 Brazilian stone-formers. A baseline 24-hour urine collection was performed prior to treatment. Details of the medical treatment initiated for stone-disease were recorded. A PSF calculation was performed on the 24 hour urine sample using the 7 urinary parameters required: voided volume, oxalate, calcium, urate, pH, citrate and magnesium. A repeat 24-hour urine sample was performed for PSF calculation after treatment. Comparison was made between the PSF scores before and during treatment.
At baseline, 20 of the 26 patients (77%) had a high PSF score (> 0.5). Of the 26 patients, 17 (65%) showed an overall reduction in their PSF profiles with a medical treatment regimen. Eleven patients (42%) changed from a high risk (PSF > 0.5) to a low risk (PSF < 0.5) and 6 patients reduced their risk score but did not change risk category. Six (23%) patients remained in a high risk category (> 0.5) during both assessments.
The PSF score reduced following medical treatment in the majority of patients in this cohort.
目的是确认复发性结石形成者接受药物治疗后结石形成概率（PSF）是否有相应变化。
收集了26名巴西结石形成者的数据。在治疗前进行了一次基线24小时尿液收集。记录了针对结石疾病开始的药物治疗细节。使用所需的7项尿液参数（排尿量、草酸盐、钙、尿酸盐、pH值、柠檬酸盐和镁）对24小时尿液样本进行PSF计算。治疗后进行重复24小时尿液样本的PSF计算。比较治疗前和治疗期间的PSF评分。
基线时，26名患者中有20名（77%）PSF评分较高（>0.5）。26名患者中，17名（65%）通过药物治疗方案其PSF概况总体下降。11名患者（42%）从高风险（PSF>0.5）转变为低风险（PSF<0.5），6名患者降低了风险评分但未改变风险类别。6名（23%）患者在两次评估中均处于高风险类别（>0.5）。
该队列中的大多数患者接受药物治疗后PSF评分降低。
