Hoshino Tatsuji, Kita Masato, Imai Yukihiro, Yamakawa Masaru
Department of Obstetrics and Gynecology, Kobe City Medical Center General Hospital, Kobe, Japan.
Pediatr Int. 2014 Aug;56(4):637-9. doi: 10.1111/ped.12386.
Congenital toxoplasmosis is caused by Toxoplasma gondii. The incidence of death due to congenital toxoplasmosis in Japan from 1974 to 2007 was calculated using the autopsy database of the Japanese Society of Pathology and vital statistics from the Ministry of Health, Labour and Welfare. Two neonatal deaths due to congenital toxoplasmosis were reported during that time. As there were 161,195 neonatal deaths during this period and 32,465 autopsies were performed, the yearly neonatal death from congenital toxoplasmosis was calculated as 2 × 161,195/32,465/34 = 0.29 and the autopsy rate as 32,465/161,195 = 0.2014 (20.14%). The calculated number of annual deaths in infants was 0.82 and in children aged 1-4 years it was 2.09; thus, although few, deaths from congenital toxoplasmosis do still occur in neonates, infants, and young children. Therefore, obstetricians and pediatricians should be aware of the potential for congenital toxoplasmosis, and pregnant women should make every effort to avoid T. gondii infection.
先天性弓形虫病由刚地弓形虫引起。利用日本病理学会的尸检数据库以及厚生劳动省的人口动态统计数据，计算了1974年至2007年期间日本先天性弓形虫病所致的死亡发生率。在此期间报告了两例因先天性弓形虫病导致的新生儿死亡。由于在此期间有161,195例新生儿死亡，且进行了32,465例尸检，因此先天性弓形虫病导致的年新生儿死亡率计算为2×161,195/32,465/34 = 0.29，尸检率为32,465/161,195 = 0.2014（20.14%）。计算得出的婴儿年死亡数为0.82，1至4岁儿童年死亡数为2.09；因此，尽管先天性弓形虫病导致的死亡很少，但在新生儿、婴儿和幼儿中仍有发生。所以，产科医生和儿科医生应意识到先天性弓形虫病的可能性，孕妇应尽力避免感染刚地弓形虫。
