Mascena Guilherme Veras, Melo Maria Cecília Santos Cavalcanti, Gadelha Diego Nery Benevides, Oliveira Thárcia Kiara Beserra, Brandt Carlos Teixeira
Health Sciences Center, Federal University of Pernambuco, Campina Grande, PB, Brazil.
Department of Ophthalmology, UFPE, Campina Grande, PB, Brazil.
Acta Cir Bras. 2014 Sep;29(9):615-21. doi: 10.1590/s0102-8650201400150010.
To evaluate the treatment outcome of severe peritonitis in rats with increasing age.
Thirty Wistar rats stratified in three groups: group I - six month-old; group II - 12 month-old; and group III - 18 month-old, underwent autogenously fecal peritonitis (6 ml/kg rat), and were treated with intravenous meropenem. The survival animals were followed-up for 45 days. The variables were expressed by their mean and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee.
There was a significant increase in the mortality and morbidity in elderly rats. Of interest, even among young survival rats presenting with severe residual abscesses both in the abdomen and thorax cavities, they present an almost normal life.
The treatment of severe autogenously fecal peritonitis with intravenous meropenem reached reasonable results in rats with six and twelve months of age, even considering residual abscesses on abdomen and thorax cavities. However, the great majority (80%) of elderly rats could not overcome the initial severe infectious challenge, proving that ageing is a very important risk factor for impairing immune response. Thus, sepsis remains a challenging situation, especially in elderly.
评估不同年龄大鼠严重腹膜炎的治疗结果。
30只Wistar大鼠分为三组：I组 - 6月龄；II组 - 12月龄；III组 - 18月龄，进行自体粪便性腹膜炎（6 ml/kg大鼠），并接受静脉注射美罗培南治疗。对存活动物随访45天。变量以均值和均值标准误（SEM）表示。p<0.05用于拒绝原假设。该研究经伦理委员会批准。
老年大鼠的死亡率和发病率显著增加。有趣的是，即使在腹部和胸腔有严重残留脓肿的年轻存活大鼠中，它们的生活也几乎正常。
静脉注射美罗培南治疗严重自体粪便性腹膜炎，在6个月和12个月龄的大鼠中取得了合理的结果，即使考虑到腹部和胸腔有残留脓肿。然而，绝大多数（80%）老年大鼠无法克服最初的严重感染挑战，证明衰老仍是损害免疫反应的一个非常重要的危险因素。因此，脓毒症仍然是一个具有挑战性的情况，尤其是在老年人中。
