Melo Maria Cecília Santos Cavalcanti, Gadelha Diego Nery Benevides, Oliveira Thárcia Kiara Beserra, Brandt Carlos Teixeira
Campina Grande Faculty of Medicine, Department of Ophthalmology, Campina GrandePB, Brazil, IFellow PhD degree, Postgraduate Program in Surgery, Health Sciences Center, Federal University of Pernambuco (UFPE). Assistant Professor, Department of Ophthalmology, Campina Grande Faculty of Medicine (FCM), Campina Grande-PB, Brazil. Acquisition and interpretation of data, manuscript writing.
FCM, Department of Ophthalmology, Campina GrandePB, Brazil, IIFellow PhD degree, Postgraduate Program in Surgery, Health Sciences Center, UFPE, Recife-PE. Associate Professor, Department of Ophthalmology, FCM, Campina Grande-PB, Brazil. Manuscript writing, critical revision.
Acta Cir Bras. 2014 Feb;29(2):76-81. doi: 10.1590/S0102-86502014000200001.
To evaluate the treatment outcome of severe peritonitis in rats submitted to permanent bilateral carotid occlusion (PBCO).
Sixteen Wistar rats (mean age of 8.5 months) with PBCO underwent autogenously fecal peritonitis, and were treated with moxifloxacin combined with dexamethasone, and followed-up for 45 days. Ten rats (mean age five months) without PBCO were used as a control group. The variables were expressed by their mean and standard error of the mean (SEM). p<0.05 was used for rejecting the null hypothesis. The study was approved by the Ethics Committee.
There was a significant increase (p=0.0002) in the mortality and morbidity in older rats that underwent PBCO (study group). However, even among the survival rats presenting with severe residual abscesses both in the abdomen and thorax cavities, they present an almost normal life.
The treatment of severe autogenously fecal peritonitis with intraperitoneal moxifloxacin combined with dexamethasone was very effective in young rats without permanent bilateral carotid occlusion. The treatment reached reasonable results in older rats with PBCO, even considering residual abscesses on abdomen and thorax. Older age was the greater risk factor for the outcome of the treatment of severe peritonitis. Sepsis remains a challenging situation, especially in elderly.
评估永久性双侧颈动脉闭塞（PBCO）大鼠严重腹膜炎的治疗效果。
16只接受PBCO的Wistar大鼠（平均年龄8.5个月）发生自发性粪性腹膜炎，接受莫西沙星联合地塞米松治疗，并随访45天。10只未接受PBCO的大鼠（平均年龄5个月）作为对照组。变量以均值和均值标准误（SEM）表示。p<0.05用于拒绝原假设。该研究经伦理委员会批准。
接受PBCO的老年大鼠（研究组）的死亡率和发病率显著增加（p=0.0002）。然而，即使在存活的大鼠中，腹部和胸腔均有严重残留脓肿，它们的生活也几乎正常。
腹腔注射莫西沙星联合地塞米松治疗年轻大鼠的自发性严重粪性腹膜炎非常有效，这些年轻大鼠未发生永久性双侧颈动脉闭塞。对于接受PBCO的老年大鼠，即使考虑到腹部和胸腔有残留脓肿，治疗也取得了合理的结果。高龄是严重腹膜炎治疗结果的更大危险因素。脓毒症仍然是一个具有挑战性的情况，尤其是在老年人中。
