新诊断高血压患者平均血小板体积与清晨血压激增的关系。
Relationship between mean platelet volume and morning blood pressure surge in newly diagnosed hypertensive patients.
作者信息
Uçar Hakan, Gür Mustafa, Gözükara Mehmet Yavuz, Kıvrak Ali, Kolcu Zekeriya, Akyol Selehattin, Kaypaklı Onur, Elbasan Zafer, Şahin Durmuş Yıldıray, Türkoğlu Caner, Şeker Taner, Çaylı Murat
机构信息
Clinic of Cardiology, Adana Numune Training and Research Hospital; Adana-Turkey.
出版信息
Anatol J Cardiol. 2015 Feb;15(2):107-12. doi: 10.5152/akd.2014.5196. Epub 2014 Apr 8.
OBJECTIVE
Morning blood pressure surge (MBPS) is an independent predictor of atherothrombotic cardiovascular events in hypertensive patients. There is evidence from studies supporting the validity of mean platelet volume (MPV) as a marker of vascular risk and predictor of thrombotic complications. The aim of this study is to investigate the relationship between MPV and MBPS in hypertensive patients.
METHODS
Measurements were obtained from 298 patients with newly diagnosed essential hypertension (Mean age: 51.9 ± 11.7 years). The patients were divided into two groups (MPV(low) group; <10.8 fL, MPV(high) group; ≥ 10.8 fL). The MBPS was calculated as mean systolic BP during the 2 hours after awaking minus the mean systolic BP during the 1 hour that included the lowest sleep BP.
RESULTS
MPV was independently associated with MBPS (β=0.554, p<0.001) and hs-CRP level (β=0.286, p<0.001).
CONCLUSION
Finally, higher MPV values related to enhanced MBPS which are associated with atherothrombotic cardiovascular events.
目的
晨峰血压（MBPS）是高血压患者动脉粥样硬化性心血管事件的独立预测因子。有研究证据支持平均血小板体积（MPV）作为血管风险标志物和血栓形成并发症预测因子的有效性。本研究旨在探讨高血压患者中MPV与MBPS之间的关系。
方法
对298例新诊断的原发性高血压患者（平均年龄：51.9±11.7岁）进行测量。患者分为两组（MPV（低）组；<10.8 fL，MPV（高）组；≥10.8 fL）。MBPS的计算方法为醒来后2小时内的平均收缩压减去包括最低睡眠血压在内的1小时内的平均收缩压。
结果
MPV与MBPS（β=0.554，p<0.001）和hs-CRP水平（β=0.286，p<0.001）独立相关。
结论
最后，较高的MPV值与增强的MBPS相关，而MBPS与动脉粥样硬化性心血管事件相关。
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